{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T13:00:21Z","timestamp":1773061221646,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,7,16]],"date-time":"2018-07-16T00:00:00Z","timestamp":1531699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Ruxolitinib is a <jats:italic><jats:styled-content style=\"fixed-case\">JAK<\/jats:styled-content>1\/2<\/jats:italic> inhibitor that may control myelofibrosis (<jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>)\u2010related splenomegaly and symptoms and can be prescribed regardless of age. While aging is known to correlate with worse prognosis, no specific analysis is available to confirm that ruxolitinib is suitable for use in older populations. A clinical database was created in 23 European Haematology Centres and retrospective data on 291 <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> patients treated with ruxolitinib when aged \u226565\u00a0years were analysed in order to assess the impact of age and molecular genotype on responses, toxicities and survival. Additional mutations were evaluated by a next generation sequencing (<jats:styled-content style=\"fixed-case\">NGS<\/jats:styled-content>) approach in 69 patients with available peripheral blood samples at the start of ruxolitinib treatment. Compared to older (age 65\u201374\u00a0years) patients, elderly (\u226575\u00a0years) showed comparable responses to ruxolitinib, but higher rates of drug\u2010induced anaemia and thrombocytopenia and worse survival. Nonetheless, the ruxolitinib discontinuation rate was comparable in the two age groups. Number and types of molecular abnormalities were comparable across age groups. However, the presence of high molecular risk (<jats:styled-content style=\"fixed-case\">HMR<\/jats:styled-content>) mutations significantly affected survival, counterbalancing the effect of aging. Indeed, elderly patients with &lt;2 <jats:styled-content style=\"fixed-case\">HMR<\/jats:styled-content> mutated genes had a comparable survival to older patients with \u22652 <jats:styled-content style=\"fixed-case\">HMR<\/jats:styled-content> mutations. Given that responses were not influenced by age, older age <jats:italic>per se<\/jats:italic> should not be a limitation for ruxolitinib administration. <jats:styled-content style=\"fixed-case\">NGS<\/jats:styled-content> analysis of <jats:styled-content style=\"fixed-case\">HMR<\/jats:styled-content> mutations also confirmed a strong predictive value in elderly patients.<\/jats:p>","DOI":"10.1111\/bjh.15497","type":"journal-article","created":{"date-parts":[[2018,7,16]],"date-time":"2018-07-16T09:12:15Z","timestamp":1531732335000},"page":"35-46","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Ruxolitinib in elderly patients with myelofibrosis: impact of age and genotype. A multicentre study on 291 elderly patients"],"prefix":"10.1111","volume":"183","author":[{"given":"Francesca","family":"Palandri","sequence":"first","affiliation":[{"name":"Institute of Haematology \u201cL. and A. 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Emanuele\u201d University of Catania Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Crugnola","sequence":"additional","affiliation":[{"name":"Division of Haematology Azienda Ospedaliero\u2010Universitaria di Parma Udine Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Abruzzese","sequence":"additional","affiliation":[{"name":"Division of Haematology Ospedale S. Eugenio Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2036-2896","authenticated-orcid":false,"given":"Daniela","family":"Bartoletti","sequence":"additional","affiliation":[{"name":"Institute of Haematology \u201cL. and A. 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