{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T05:16:17Z","timestamp":1754111777602,"version":"3.37.3"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,8,3]],"date-time":"2018-08-03T00:00:00Z","timestamp":1533254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Prevention of infections is of obvious relevance in paediatric patients with acute myeloid leukaemia (<jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>). However, recommendations are often non\u2010specific and supported by low\u2010quality evidence, resulting in divergent infection preventive regimens. Using a web\u2010based survey, we investigated the infection prophylaxis guidelines of 22 paediatric <jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content> study groups affiliated to the international Berlin\u2013Frankf\u00fcrt\u2013M\u00fcnster study group. In order to evaluate differences in daily practice among hospitals, representatives (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>27) from the Nordic Society for Paediatric Haematology and Oncology\u2010Dutch\u2010Belgium\u2010Hong Kong \u2010 <jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content> study group participated in a slightly modified survey. Seven study groups (32%) advise gram\u2010negative antibiotic prophylaxis, mainly with fluoroquinolones (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>6). Gram\u2010positive prophylaxis is prescribed by eight groups (36%). Over 60% of the study groups prescribe food and social restrictions, but the specific topics and strictness differ widely. According to the hospital\u2010based survey, sites roughly comply with common study group guidelines. However, the use of any gram\u2010negative antibiotic prophylaxis, the specific prophylactic antifungal agent and the strictness of the food and social restrictions differ substantially between the hospitals. Despite a long history of close collaboration, many differences are still present between the affiliated groups. The results of this survey provide an appropriate baseline measure to study the emergence and impact of future guidelines on infection prophylaxis in paediatric <jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/bjh.15499","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T05:16:12Z","timestamp":1533618972000},"page":"87-95","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Differences in infection prophylaxis measures between paediatric acute myeloid leukaemia study groups within the international Berlin\u2013Frankf\u00fcrt\u2013M\u00fcnster (I\u2010<scp>BFM<\/scp>) study group"],"prefix":"10.1111","volume":"183","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9794-1071","authenticated-orcid":false,"given":"Kim","family":"Klein","sequence":"first","affiliation":[{"name":"Department of Pediatric Oncology\/Hematology VU University Medical Center Amsterdam The Netherlands"},{"name":"Department of Pediatrics University Medical Center Utrecht\/Wilhelmina Children's Hospital Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Hasle","sequence":"additional","affiliation":[{"name":"Department of Oncology Aarhus University Hospital Skejby Aarhus Denmark"},{"name":"Nordic Pediatric Hematology and Oncology group Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas","family":"Abrahamsson","sequence":"additional","affiliation":[{"name":"Nordic Pediatric Hematology and Oncology group Gothenburg Sweden"},{"name":"Department of Pediatric Oncology Queen Silvia Children's Hospital Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"De Moerloose","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\u2010Oncology and Stem Cell Transplantation Ghent University Hospital Ghent Belgium"},{"name":"Belgian Society of Paediatric Haematology Oncology Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gertjan J. 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