{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:35:26Z","timestamp":1790508926296,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,8,10]],"date-time":"2018-08-10T00:00:00Z","timestamp":1533859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["5U01CA157581\u201005"],"award-info":[{"award-number":["5U01CA157581\u201005"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Mantle cell lymphoma (<jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content>) is still considered incurable and the course of the disease is highly variable. Established risk factors include the Mantle Cell Lymphoma International Prognostic Index (<jats:styled-content style=\"fixed-case\">MIPI<\/jats:styled-content>) and the quantification of the proliferation rate of the tumour cells, e.g. by Ki\u201067 immunohistochemistry. In this study, we aimed to validate the prognostic value of the gene expression\u2010based <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content>35 proliferation assay in patient cohorts from randomized trials of the European Mantle Cell Lymphoma Network. Using this assay, we analysed the gene expression proliferation signature in routine diagnostic lymph node specimens from <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content> Younger and <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content> Elderly trial patients, and the calculated <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content>35 score was used to assign <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content> patients to low (61%), standard (27%) or high (12%) risk groups with significantly different outcomes. We confirm here in our prospective clinical trial cohort of <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content> patients, that the <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content>35 assay is strongly prognostic, providing additional information to the Ki\u201067 index and the <jats:styled-content style=\"fixed-case\">MIPI<\/jats:styled-content>. Thus, this robust assay may assist in making treatment decisions or in devising risk\u2010adapted prospective clinical trials in the future.<\/jats:p>","DOI":"10.1111\/bjh.15519","type":"journal-article","created":{"date-parts":[[2018,8,10]],"date-time":"2018-08-10T10:35:13Z","timestamp":1533897313000},"page":"616-624","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Validation of the <scp>MCL<\/scp>35 gene expression proliferation assay in randomized trials of the European Mantle Cell Lymphoma Network"],"prefix":"10.1111","volume":"184","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5535-2412","authenticated-orcid":false,"given":"Hilka","family":"Rauert\u2010Wunderlich","sequence":"first","affiliation":[{"name":"Institute of Pathology University of W\u00fcrzburg and Comprehensive Cancer Centre (CCC) Mainfranken W\u00fcrzburg 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C.","family":"Kluin\u2010Nelemans","sequence":"additional","affiliation":[{"name":"Department of Haematology University Medical Centre Groningen University of Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Hermine","sequence":"additional","affiliation":[{"name":"Department of Haematology Necker Hospital Public Assistance \u2010 Hospital of Paris University Paris Descartes Paris France"},{"name":"Imagine Institute University of Sorbonne Paris City Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Dr. Senckenberg Institute of Pathology Goethe University Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Thorns","sequence":"additional","affiliation":[{"name":"Institute of Pathology Marienkrankenhaus Hamburg 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