{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:25:51Z","timestamp":1788542751316,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,8,16]],"date-time":"2018-08-16T00:00:00Z","timestamp":1534377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Assessment of minimal residual disease (<jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content>) is being routinely used to assess response in patients with acute myeloid leukaemia (<jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>). While it is well established that pre\u2010transplant positive <jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content> studies predict for relapse in patients transplanted either from matched sibling donors or matched unrelated donors, it is currently unknown whether <jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content> has comparable prognostic value in haploidentical stem cell transplantation (haplo\u2010<jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content>). To this end we performed a retrospective analysis using the Acute Leukaemia Working Party\/European Society of Blood and Marrow Transplantation multicentre registry. All adult <jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content> patients with known <jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content> status at transplant who underwent a first T\u2010cell replete haplo\u2010<jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content> while in remission between 2006 and 2016 were included. Two hundred and sixty\u2010five <jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content>\u2010negative and 128 <jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content>\u2010positive patients were assessed. In multivariate analysis, <jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content>\u2010negative patients experienced lower relapse incidence and better leukaemia\u2010free survival (<jats:styled-content style=\"fixed-case\">LFS<\/jats:styled-content>) compared to <jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content>\u2010positive patients. Subset analysis for <jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content>\u2010positive patients revealed that patients with donors positive for cytomegalovirus experienced decreased relapse rates as well as increased survival. A 6\u2010month landmark analysis suggests that the clinical benefit of pre\u2010transplant <jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content> negativity in terms of relapse, overall survival and <jats:styled-content style=\"fixed-case\">LFS<\/jats:styled-content> is realized at this time point. Pre\u2010transplant <jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content> status is potentially a pivotal prognosticator of outcome in <jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content> patients undergoing T\u2010cell replete haplo\u2010<jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/bjh.15540","type":"journal-article","created":{"date-parts":[[2018,8,17]],"date-time":"2018-08-17T03:57:45Z","timestamp":1534478265000},"page":"411-420","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Minimal residual disease status predicts outcome of acute myeloid leukaemia patients undergoing T\u2010cell replete haploidentical transplantation. An analysis from the Acute Leukaemia Working Party (<scp>ALWP<\/scp>) of the European Society for Blood and Marrow Transplantation (<scp>EBMT<\/scp>)"],"prefix":"10.1111","volume":"183","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5294-3524","authenticated-orcid":false,"given":"Jonathan","family":"Canaani","sequence":"first","affiliation":[{"name":"Haematology Division Chaim Sheba Medical Centre Tel Aviv University Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Labopin","sequence":"additional","affiliation":[{"name":"EBMT Paris study office\/CEREST\u2010TC Hopital Saint\u2010Antoine Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2145-6643","authenticated-orcid":false,"given":"Xiao J.","family":"Huang","sequence":"additional","affiliation":[{"name":"Haematology Peking University People\u2032s Hospital Peking 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