{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T08:55:54Z","timestamp":1774083354680,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,8,20]],"date-time":"2018-08-20T00:00:00Z","timestamp":1534723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>) is a serious complication of sickle cell anaemia (<jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content>). We set out to describe the burden, presentation and organisms associated with <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content> amongst children with <jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content> attending Mulago Hospital, Kampala, Uganda. In a cross\u2010sectional study, 256 children with <jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content> and fever attending Mulago Hospital were recruited. Chest X\u2010rays, blood cultures, complete blood count and sputum induction were performed. Sputum samples were investigated by Ziehl\u2010Nielsen staining, culture and <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> polymerase chain reaction (<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>) for <jats:italic>Chlamydia pneumoniae<\/jats:italic>. Of the 256 children, 22\u00b77% had <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>. Clinical and laboratory findings were not significantly different between children with <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content> and those without, besides cough and abnormal signs on auscultation. Among the 83 sputum cultures <jats:italic>Streptococcus pneumoniae<\/jats:italic> (12%) and <jats:italic>Moraxella<\/jats:italic> spp (8%), were the commonest. Of the 59 sputa examined with <jats:styled-content style=\"fixed-case\">DNA PCR<\/jats:styled-content>, 59\u00b73% were positive for <jats:italic>Chlamydia pneumoniae<\/jats:italic>. <jats:italic>Mycobacterium tuberculosis<\/jats:italic> was isolated in 6\/83 sputa. These results show that one in 5 <jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content> febrile children had <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>. There were no clinical and laboratory characteristics of <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>, but cough and abnormalities on auscultation were associated with <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>. The high prevalence of <jats:italic>Chlamydia pneumoniae<\/jats:italic> in children with <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content> in this setting warrants the addition of macrolides to treatment, and <jats:italic>M.\u00a0tuberculosis<\/jats:italic> should be differential in sub\u2010Saharan children with <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/bjh.15543","type":"journal-article","created":{"date-parts":[[2018,8,20]],"date-time":"2018-08-20T16:53:27Z","timestamp":1534784007000},"page":"289-297","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<scp>ACS<\/scp> in children with sickle cell anaemia in Uganda: prevalence, presentation and aetiology"],"prefix":"10.1111","volume":"183","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9240-6109","authenticated-orcid":false,"given":"Odong","family":"Ochaya","sequence":"first","affiliation":[{"name":"Department of Paediatrics and Child Health School of Medicine, College of Health Sciences (CHS) Makerere University Kampala Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather","family":"Hume","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health School of Medicine, College of Health Sciences (CHS) Makerere University Kampala Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam","family":"Bugeza","sequence":"additional","affiliation":[{"name":"Department of Radiology School of Medicine, College of Health Sciences Makerere University Kampala Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Freddie","family":"Bwanga","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology School of Biomedical Sciences, College of Health Sciences Makerere University Kampala Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosemary","family":"Byanyima","sequence":"additional","affiliation":[{"name":"Department of Radiology School of Medicine, College of Health Sciences Makerere University Kampala Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harriet","family":"Kisembo","sequence":"additional","affiliation":[{"name":"Department of Radiology School of Medicine, College of Health Sciences Makerere University Kampala Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James K.","family":"Tumwine","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health School of Medicine, College of Health Sciences (CHS) Makerere University Kampala Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1989.tb24159.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/1817-1737.36550"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(85)80230-4"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.2.643.643"},{"key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1001\/archinte.1979.03630380047016","article-title":"\u201cAcute chest syndrome\u201d in adults with sickle cell anemia. 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(2010)Sickle\u2010Cell Disease: A Strategy for the WHO African Region.World Health Organisation Regional office for Africa Malabo Equatorial Guinea."}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjh.15543","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.15543","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T12:46:29Z","timestamp":1694868389000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.15543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,20]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1111\/bjh.15543"],"URL":"https:\/\/doi.org\/10.1111\/bjh.15543","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,20]]},"assertion":[{"value":"2018-03-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}