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However recent studies have shown that macrophages play a critical role in regulating the half\u2010life of <jats:styled-content style=\"fixed-case\">VWF<\/jats:styled-content>, and have identified specific lectin (including asialoglycoprotein, macrophage galactose\u2010type lectin, Sigec\u20105 and C\u2010type lectin domain family 4 member M) and scavenger receptors (including low\u2010density lipoprotein receptor\u2010related protein\u20101, scavenger receptor A1 and stabilin\u20102) that are involved in <jats:styled-content style=\"fixed-case\">VWF<\/jats:styled-content> clearance. Further studies will be required to determine the relative importance of these individual receptors with respect to physiological and pathological <jats:styled-content style=\"fixed-case\">VWF<\/jats:styled-content> clearance. Nevertheless, recent clinical data have highlighted the importance of enhanced <jats:styled-content style=\"fixed-case\">VWF<\/jats:styled-content> clearance in the pathogenesis of type 1 von Willebrand disease (<jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content>). Moreover, increased clearance also contributes to reduced <jats:styled-content style=\"fixed-case\">VWF<\/jats:styled-content> levels in many patients with type 2 and type 3 <jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content>. Improved understanding regarding <jats:styled-content style=\"fixed-case\">VWF<\/jats:styled-content> clearance is not only of direct biological relevance, but may also have important implications for the development of novel therapeutic agents with extended plasma half\u2010lives for the treatment of both <jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content> and haemophilia A.<\/jats:p>","DOI":"10.1111\/bjh.15565","type":"journal-article","created":{"date-parts":[[2018,10,31]],"date-time":"2018-10-31T03:24:11Z","timestamp":1540956251000},"page":"185-195","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["von Willebrand factor clearance \u2013 biological mechanisms and clinical significance"],"prefix":"10.1111","volume":"183","author":[{"given":"Jamie M.","family":"O'Sullivan","sequence":"first","affiliation":[{"name":"Haemostasis Research Group Irish Centre for Vascular Biology Royal College of 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