{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:22:40Z","timestamp":1740126160402,"version":"3.37.3"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,9,11]],"date-time":"2018-09-11T00:00:00Z","timestamp":1536624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Bendamustine is used in combination with rituximab (<jats:styled-content style=\"fixed-case\">BR<\/jats:styled-content>) to treat indolent non\u2010Hodgkin lymphomas (<jats:styled-content style=\"fixed-case\">iNHL<\/jats:styled-content>) and mantle cell lymphoma (<jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content>). The variability in treatment efficacy and toxicity could be related to single nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s) in immune response genes. We would like to show a correlation between <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s and treatment outcome in <jats:styled-content style=\"fixed-case\">iNHL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content> patients receiving <jats:styled-content style=\"fixed-case\">BR<\/jats:styled-content>. We investigated some <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s that had already been associated with <jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content> outcome. Samples were genotyped for the <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>2<\/jats:italic> (rs2069762), <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>10<\/jats:italic> (rs1800890, rs10494879), <jats:italic><jats:styled-content style=\"fixed-case\">VEGFA<\/jats:styled-content><\/jats:italic> (rs3025039), <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>8<\/jats:italic> (rs4073), <jats:italic><jats:styled-content style=\"fixed-case\">CFH<\/jats:styled-content><\/jats:italic> (rs1065489) and <jats:italic><jats:styled-content style=\"fixed-case\">MTHFR<\/jats:styled-content><\/jats:italic> (rs1801131) <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s by allelic discrimination assays. We enrolled 70 patients that received rituximab 375\u00a0mg\/m<jats:sup>2<\/jats:sup> and bendamustine 90\u00a0mg\/m<jats:sup>2<\/jats:sup> every 28\u00a0days, both as first\u2010line treatment and \u2265 second\u2010line regimens. Overall response rate was 97\u00b71% (complete response [<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>] rate 73\u00b79%). Treatment toxicity included grade 3\u20134 neutropenia (24\/70 patients), infections (21\/70 patients; 1\/70 grade 3), skin rash (26\/70 patients; 2\/70 grade 3). After a median follow\u2010up of 24\u00a0months we did find any correlation between the analysed <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s, <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content> rate and <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content>. However, we demonstrated an association between the <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>2 (rs2069762) and the onset of skin rash (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b70001). Our study suggests a role for cytokine <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s in bendamustine\u2010related toxicity, which could represent a promising research field.<\/jats:p>","DOI":"10.1111\/bjh.15582","type":"journal-article","created":{"date-parts":[[2018,9,11]],"date-time":"2018-09-11T08:29:43Z","timestamp":1536654583000},"page":"223-231","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Study of gene polymorphisms as predictors of treatment efficacy and toxicity in patients with indolent non\u2010hodgkin lymphomas and mantle cell lymphoma receiving bendamustine and rituximab"],"prefix":"10.1111","volume":"184","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0432-9706","authenticated-orcid":false,"given":"Emanuele","family":"Cencini","sequence":"first","affiliation":[{"name":"Unit of Haematology Azienda Ospedaliera Universitaria Senese Siena Italy"},{"name":"University of Siena Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Sicuranza","sequence":"additional","affiliation":[{"name":"Unit of Haematology Azienda Ospedaliera Universitaria Senese Siena Italy"},{"name":"University of Siena Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Fabbri","sequence":"additional","affiliation":[{"name":"Unit of Haematology Azienda Ospedaliera Universitaria Senese Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Ferrigno","sequence":"additional","affiliation":[{"name":"Unit of Haematology Azienda Ospedaliera Universitaria Senese Siena Italy"},{"name":"University of Siena Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Rigacci","sequence":"additional","affiliation":[{"name":"Haematology Department University of Florence Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8597-8459","authenticated-orcid":false,"given":"Maria C.","family":"Cox","sequence":"additional","affiliation":[{"name":"Haematology Department Ospedale S. 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