{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:51:27Z","timestamp":1790754687095,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T00:00:00Z","timestamp":1536537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2019,2]]},"abstract":"Summary<\/jats:title>The diagnosis of Waldenstr\u00f6m Macroglobulinaemia (WM<\/jats:styled-content>)\/lymphoplasmacytic lymphoma (LPL<\/jats:styled-content>) remains one of exclusion because other B\u2010cell lymphoproliferative disorders (B\u2010LPD<\/jats:styled-content>), such as marginal zone lymphoma (MZL<\/jats:styled-content>), can fulfil similar criteria, including MYD<\/jats:styled-content>88<\/jats:italic> L265P mutation. It has been suggested that expression of the myeloid marker CD<\/jats:styled-content>13 (also termed ANPEP<\/jats:styled-content>) is more frequent in LPL<\/jats:styled-content> than in other B\u2010LPD<\/jats:styled-content> and has also been described on normal and malignant plasma cells. Here, CD<\/jats:styled-content>13 expression was tested in a cohort of 1037 B\u2010LPD<\/jats:styled-content> patients from 3 centres by flow cytometry. The percentage of CD<\/jats:styled-content>13\u2010expressing cells was found to be variable among B\u2010LPD<\/jats:styled-content> but significantly higher in WM<\/jats:styled-content>\/LPL<\/jats:styled-content> (median 31% vs. 0% in non\u2010WM<\/jats:styled-content>\/LPL<\/jats:styled-content>, P<\/jats:italic>\u00a0<\u00a00\u00b7001). In multivariate linear regression, CD<\/jats:styled-content>13 expression remained significantly associated with a diagnosis of WM<\/jats:styled-content>\/LPL<\/jats:styled-content> (P<\/jats:italic>\u00a0<\u00a00\u00b7001). A cut\u2010off value of 2% of CD<\/jats:styled-content>19+<\/jats:sup> cells co\u2010expressing CD<\/jats:styled-content>13 yielded the best diagnostic performance for WM<\/jats:styled-content>\/LPL<\/jats:styled-content> assertion. This was further improved by association with the presence or absence of IgM paraprotein. Finally, given that previously published transcriptomic data revealed no difference in CD<\/jats:styled-content>13<\/jats:italic> (also termed ANPEP<\/jats:styled-content><\/jats:italic>) mRNA<\/jats:styled-content> between normal and pathological B\u2010cells, the hypothesis of some post\u2010transcriptional regulation must be favoured. These results suggest that testing for CD<\/jats:styled-content>13 expression in routine flow cytometry panels could help to discriminate WM<\/jats:styled-content>\/LPL<\/jats:styled-content> from other B\u2010LPD<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/bjh.15584","type":"journal-article","created":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T10:59:14Z","timestamp":1536577154000},"page":"625-633","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["CD<\/scp>13 expression in B cell malignancies is a hallmark of plasmacytic differentiation"],"prefix":"10.1111","volume":"184","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7368-2247","authenticated-orcid":false,"given":"Anna","family":"Raimbault","sequence":"first","affiliation":[{"name":"Service d'H\u00e9matologie Biologique H\u00f4pitaux Universitaires Paris Centre Universit\u00e9 Paris Descartes Paris 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