{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:45:35Z","timestamp":1787013935631,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T00:00:00Z","timestamp":1539820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007560","name":"Chiesi Farmaceutici","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007560","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    We prospectively assessed the efficacy of deferasirox\n                    <jats:italic>versus<\/jats:italic>\n                    deferiprone or desferrioxamine as monotherapy in thalassaemia major (TM) patients by magnetic resonance imaging (MRI). We selected the patients enrolled in the Myocardial Iron Overload in Thalassaemia network who received only one chelator between two MRIs (deferasirox\u00a0=\u00a0235, deferiprone\u00a0=\u00a0142, desferrioxamine\u00a0=\u00a0162). Iron overload was measured by T2* technique and biventricular function by cine images. Among the patients with baseline myocardial iron, in all three groups there was a significant improvement in global heart T2* values. The deferiprone and desferrioxamine groups showed a significant improvement in left ventricular ejection fraction (LVEF). Only the deferiprone group showed a significant improvement in right ventricular ejection fraction (RVEF). The improvement in global heart T2* was significantly lower in the deferasirox\n                    <jats:italic>versus<\/jats:italic>\n                    the deferiprone group. The improvement in the LVEF was significantly higher in the deferiprone and desferrioxamine groups than in the deferasirox group and the improvement in the RVEF was significantly higher in the deferiprone than in deferasirox group. Among the patients with baseline hepatic iron, the changes in hepatic iron were comparable in deferasirox\n                    <jats:italic>versus<\/jats:italic>\n                    the other groups. Deferasirox monotherapy was less effective than deferiprone in improving myocardial siderosis and biventricular function and less effective than desferrioxamine in improving the LVEF.\n                  <\/jats:p>","DOI":"10.1111\/bjh.15595","type":"journal-article","created":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T06:59:08Z","timestamp":1539845948000},"page":"783-795","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["MRI multicentre prospective survey in thalassaemia major patients treated with deferasirox\n                    <i>versus<\/i>\n                    deferiprone and desferrioxamine"],"prefix":"10.1111","volume":"183","author":[{"given":"Alessia","family":"Pepe","sequence":"first","affiliation":[{"name":"Magnetic Resonance Imaging Unit Fondazione G. Monasterio CNR\u2010Regione Toscana Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2284-8585","authenticated-orcid":false,"given":"Antonella","family":"Meloni","sequence":"additional","affiliation":[{"name":"Magnetic Resonance Imaging Unit Fondazione G. Monasterio CNR\u2010Regione Toscana Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Pistoia","sequence":"additional","affiliation":[{"name":"Magnetic Resonance Imaging Unit Fondazione G. Monasterio CNR\u2010Regione Toscana Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liana","family":"Cuccia","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa Complessa Ematologia con Talassemia ARNAS Civico \u201cBenfratelli\u2010Di Cristina\u201d Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria R.","family":"Gamberini","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa di Day Hospital della Talassemia e delle Emoglobinopatie Azienda Ospedaliero\u2010Universitaria \u201cS. Anna\u201d Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Lisi","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa Dipartimentale Talassemia Presidio Ospedaliero Garibaldi\u2010Centro \u2013 ARNAS Garibaldi Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico G.","family":"D'Ascola","sequence":"additional","affiliation":[{"name":"Centro Microcitemie Azienda Ospedaliera \u201cBianchi\u2010Melacrino\u2010Morelli\u201d Reggio Calabria Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosamaria","family":"Rosso","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa Talassemie ed Emoglobinopatie Ospedale \u201cFerrarotto\u201d \u2013 Azienda Ospedaliero\u2010Universitaria Policlinico \u201cVittorio Emanuele\u201d Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"All\u00f2","sequence":"additional","affiliation":[{"name":"Servizio Microcitemia Presidio Ospedaliero ASL 5 Crotone Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Spasiano","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa Semplice Dipartimentale Malattie Rare del Globulo Rosso Azienda Ospedaliera di Rilievo Nazionale \u201cA. Cardarelli\u201d Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gennaro","family":"Restaino","sequence":"additional","affiliation":[{"name":"Dipartimento di Immagini Fondazione di Ricerca e Cura \u201cGiovanni Paolo II\u201d Campobasso Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Righi","sequence":"additional","affiliation":[{"name":"Diagnostica per Immagini e Radiologia Interventistica Ospedale del Delta Lagosanto, Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Mangione","sequence":"additional","affiliation":[{"name":"U.O.S. Sistemi informativi (UOSI) Fondazione G. Monasterio CNR\u2010Regione Toscana Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Positano","sequence":"additional","affiliation":[{"name":"Magnetic Resonance Imaging Unit Fondazione G. 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