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We report mature data from one of the first prospective SSA cohorts. Patients aged \u226518\u00a0years with DLBCL were enrolled in Malawi 2013\u20132017. Participants were treated with CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) chemotherapy and concurrent antiretroviral therapy (ART) if positive for human immunodeficiency virus (HIV+). Eighty\u2010six participants (mean age 47\u00a0years, standard deviation 13) were enrolled: 54 (63%) were male and 51 (59%) were HIV+, of whom 34 (67%) were on ART at DLBCL diagnosis. Median CD4 count was 0\u00b7113 cells\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/l (interquartile range [IQR] 0\u00b7062\u20130\u00b7227) and 25 (49%) had HIV viral load &lt;400\u00a0copies\/\u03bcl. Participants received median six cycles CHOP (IQR 4\u20136). No patients were lost to follow\u2010up and the 2\u2010year overall survival was 38% (95% confidence interval 28\u201349). In multivariable analyses, Eastern Cooperative Oncology Group performance status (PS) \u22652 and lactate dehydrogenase (LDH) &gt;2\u00d7 upper limit of normal (ULN) were associated with mortality. HIV status was not associated with mortality. A simplified prognostic model of LDH &gt;2\u00d7 ULN and PS \u22652 performed at least as well as the age\u2010adjusted International Prognostic Index. DLBCL can be successfully treated in SSA and outcomes did not differ by HIV status. A simplified prognostic model prognosticates well and may be easier to use in resource\u2010limited settings but requires validation.<\/jats:p>","DOI":"10.1111\/bjh.15625","type":"journal-article","created":{"date-parts":[[2018,11,19]],"date-time":"2018-11-19T02:25:25Z","timestamp":1542594325000},"page":"364-372","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Mature outcomes and prognostic indices in diffuse large B\u2010cell lymphoma in Malawi: a prospective cohort"],"prefix":"10.1111","volume":"184","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9175-7436","authenticated-orcid":false,"given":"Matthew S.","family":"Painschab","sequence":"first","affiliation":[{"name":"UNC Project\u2010Malawi Lilongwe Malawi"},{"name":"University of North Carolina Chapel Hill NC 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