{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:25:11Z","timestamp":1790673911818,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T00:00:00Z","timestamp":1541635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Splenectomy in addition to immunotherapy with rituximab can provide quick and sometimes durable disease control in patients with splenic marginal zone lymphoma (SMZL). However, systemic chemotherapy is ultimately required in many cases. The BRISMA (Bendamustine\u2010rituximab as first\u2010line treatment of splenic marginal zone lymphoma)\/IELSG (International Extranodal Lymphoma Study Group)36 trial is an open\u2010label, single arm phase II study designed by the IELSG in cooperation with the Fondazione Italiana Linfomi and the lymphoma Study Association according to Simon's two\u2010stage method. The primary endpoint was complete response rate. Fifty\u2010six patients with SMZL diagnosis confirmed on central revision were treated with bendamustine (90\u00a0mg\/m<jats:sup>2<\/jats:sup>\u00a0days 1, 2) and rituximab (375\u00a0mg\/m<jats:sup>2<\/jats:sup>\u00a0day 1) every 28\u00a0days for six cycles (B\u2010R). The overall response and CR rates were 91% and 73%, respectively. Duration of response, progression\u2010free survival and overall survival at 3\u00a0years were 93% (95% confidence interval [CI] 81\u201398), 90% (95% CI 77\u201396) and 96% (95% CI 84\u201398), respectively. Toxicity was mostly haematological. Neutropenia grade \u22653 was recorded in 43% of patients; infections and febrile neutropenia in 5\u00b74% and 3\u00b76%. Overall, 14 patients (25%) experienced serious adverse events. Five patients (9%) went off\u2010study because of toxicity and one patient died from infection. In conclusion, B\u2010R resulted in a very effective first\u2010line regimen for SMZL. Based on the results achieved in the BRISMA trial, B\u2010R should be considered when a chemotherapy combination with rituximab is deemed necessary for symptomatic SMZL patients.<\/jats:p>","DOI":"10.1111\/bjh.15641","type":"journal-article","created":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T14:59:57Z","timestamp":1541689197000},"page":"755-765","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Efficacy of bendamustine and rituximab in splenic marginal zone lymphoma: results from the phase II BRISMA\/IELSG36 study"],"prefix":"10.1111","volume":"183","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5044-5820","authenticated-orcid":false,"given":"Emilio","family":"Iannitto","sequence":"first","affiliation":[{"name":"Department of Oncology \u2010 Haematology Unit AOU Policlinico P. 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