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In a single\u2010centre, retrospective study, we evaluated the long\u2010term effect of\n                    <jats:styled-content style=\"fixed-case\">RAAS<\/jats:styled-content>\n                    blocking agents on proteinuria and declining estimated glomerular filtration rates (\n                    <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>\n                    ). Eighty\u2010six patients on\n                    <jats:styled-content style=\"fixed-case\">RAAS<\/jats:styled-content>\n                    blocking agents for proteinuria, followed for a median of 2\u00b728\u00a0years, were compared with 68 patients with proteinuria followed for 2\u00b724\u00a0years who were not receiving such treatment. The log odds of proteinuria decreased over time in patients on\n                    <jats:styled-content style=\"fixed-case\">RAAS<\/jats:styled-content>\n                    blocking agents (\u03b2: \u22120\u00b723,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00\u00b703) and in the non\u2010treatment group (\u03b2:\u00a0\u22120\u00b754,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00\u00b70001), but was not statistically different between both groups (\u03b2: 0\u00b731,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00\u00b7063). The\n                    <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>\n                    declined over time in patients on\n                    <jats:styled-content style=\"fixed-case\">RAAS<\/jats:styled-content>\n                    blocking agents (\u03b2: \u22122\u00b778,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00\u00b70001) and in those not on such treatment (\u03b2: \u22124\u00b77,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00\u00b70001), and was statistically different between both groups (\u03b2: 1\u00b79,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00\u00b70002). Baseline\n                    <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>\n                    was associated with mortality (Hazard rato: 0\u00b797,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00\u00b70001), but\n                    <jats:styled-content style=\"fixed-case\">RAAS<\/jats:styled-content>\n                    blocking agents had no significant effect on mortality. These data suggest that\n                    <jats:styled-content style=\"fixed-case\">RAAS<\/jats:styled-content>\n                    blockade may slow the loss of kidney function in SCD.\n                  <\/jats:p>","DOI":"10.1111\/bjh.15651","type":"journal-article","created":{"date-parts":[[2018,11,21]],"date-time":"2018-11-21T05:40:28Z","timestamp":1542778828000},"page":"246-252","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Effect of renin\u2010angiotensin\u2010aldosterone system blocking agents on progression of glomerulopathy in sickle cell disease"],"prefix":"10.1111","volume":"184","author":[{"given":"Ashley","family":"Thrower","sequence":"first","affiliation":[{"name":"School of Medicine University of North Carolina Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily J.","family":"Ciccone","sequence":"additional","affiliation":[{"name":"Division of Infectious 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