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To determine the possible contribution of lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> to the pathogenesis of follicular lymphoma (<jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>) we performed <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010sequencing at high depth sequencing in primary <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content> samples ranging from grade 1\u20103A to aggressive grade 3B variants using unpurified (<jats:italic>n<\/jats:italic>\u00a0=\u00a016) and purified (<jats:italic>n<\/jats:italic>\u00a0=\u00a012) tumour cell suspensions from nodal samples. <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content> grade 3B had a significantly higher number of differentially expressed lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s (dif\u2010lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s) with potential target coding genes related to cell cycle regulation. Nine out of the 18 selected dif\u2010lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s were validated by quantitative real time polymerase chain reaction in an independent series (<jats:italic>n<\/jats:italic>\u00a0=\u00a043) of <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">RP<\/jats:styled-content>4\u2010694A7.2 was identified as the top deregulated lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> potentially involved in cell proliferation. <jats:styled-content style=\"fixed-case\">RP<\/jats:styled-content>4\u2010694A7.2 silencing in the <jats:styled-content style=\"fixed-case\">WSU<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">FSCCL FL<\/jats:styled-content> cell line reduced cell proliferation due to a block in the G1\/S phase. The relationship between <jats:styled-content style=\"fixed-case\">RP<\/jats:styled-content>4\u2010694A7.2 and proliferation was confirmed in primary samples as its expression levels positively related to the Ki\u201067 proliferation index. In summary, lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s are differentially expressed across the clinico\u2010biological spectrum of <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content> and a subset of them, related to cell cycle, may participate in cell proliferation regulation in these tumours.<\/jats:p>","DOI":"10.1111\/bjh.15656","type":"journal-article","created":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T13:28:36Z","timestamp":1545226116000},"page":"373-383","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Differential expression of long non\u2010coding <scp>RNA<\/scp>s are related to proliferation and histological diversity in follicular lymphomas"],"prefix":"10.1111","volume":"184","author":[{"given":"Alejandro","family":"Roisman","sequence":"first","affiliation":[{"name":"Lymphoid Neoplasm Programme Institut d'Investigacions Biom\u00e8diques August Pi i 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August Pi i Sunyer (IDIBAPS) Barcelona Spain"},{"name":"Department of Pathology Hospital Cl\u00ednic University of Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"P\u00e9rez\u2010Galan","sequence":"additional","affiliation":[{"name":"Lymphoid Neoplasm Programme Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Esteve\u2010Codina","sequence":"additional","affiliation":[{"name":"CNAG\u2010CRG Centre for Genomic Regulation (CRG) Barcelona Institute of Science and Technology (BIST) Barcelona Spain"},{"name":"Universitat Pompeu Fabra (UPF) Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Dabad","sequence":"additional","affiliation":[{"name":"CNAG\u2010CRG Centre for Genomic Regulation (CRG) Barcelona Institute of Science and Technology (BIST) Barcelona 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