{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:34:13Z","timestamp":1760189653786,"version":"3.37.3"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T00:00:00Z","timestamp":1541980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Grant-in-Aid for Scientific Research"},{"name":"National Cancer Research and Development Fund","award":["29-A-3"],"award-info":[{"award-number":["29-A-3"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The chromosomal abnormalities associated with follicular lymphoma (FL) prognosis are not fully elucidated. Here, we evaluated the pattern of chromosomal abnormalities in FL, and clarified the correlations between the cytogenetic features and clinical outcome. Cytogenetic analysis was performed using standard methods of Giemsa\u2010banding at diagnosis for 201 FL patients admitted to our hospitals between 2001 and 2013. The identified chromosomal abnormalities were: t(14;18)(q32;q21) (59\u00b72%), +X (17\u00b79%), del(6)(q)\/\u20106 (16\u00b79%), +7 (14\u00b74%), abnormality of 1q12\u201021\/1q (12\u00b79%), del(13)(q)\/\u201013 (11\u00b79%), abnormality of 3q27 (10\u00b74%), abnormality of 10q22\u201024 (10\u00b70%), +12\/dup(12)(q) (10\u00b70%), abnormality of 1p21\u201022\/1p (9\u00b70%), +18 (9\u00b70%), del(17)(p)\/\u201017 (5\u00b70%), and a complex karyotype (54\u00b77%). Patients with trisomy 21 had a significantly shorter progression\u2010free survival (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b700171) and overall survival (OS) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001) than those without trisomy 21; additionally, patients with trisomy 21 in the rituximab\u2010treated cohort also had a significantly shorter OS (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7000428). Multivariate analysis identified trisomy 21 as an independent risk factor in our cohorts with or without t(14;18) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7015). In conclusion, the presence of trisomy 21 was an independent risk factor for in FL. Chromosomal analysis of FL patients at diagnosis can provide useful information about their expected survival.<\/jats:p>","DOI":"10.1111\/bjh.15664","type":"journal-article","created":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T11:05:16Z","timestamp":1542020716000},"page":"570-577","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prognostic impact of trisomy 21 in follicular lymphoma"],"prefix":"10.1111","volume":"184","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3957-1401","authenticated-orcid":false,"given":"Takeki","family":"Mitsui","sequence":"first","affiliation":[{"name":"Department of Haematology Gunma University Graduate School of Medicine Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Yokohama","sequence":"additional","affiliation":[{"name":"Division of Blood Transfusion Service Gunma University Hospital Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromi","family":"Koiso","sequence":"additional","affiliation":[{"name":"Department of Haematology Gunma University Graduate School of Medicine Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akio","family":"Saito","sequence":"additional","affiliation":[{"name":"Fujioka General Hospital Fujioka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohtaro","family":"Toyama","sequence":"additional","affiliation":[{"name":"Fujioka General Hospital Fujioka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Haematology Gunma University Graduate School of Medicine Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuma","family":"Ishizaki","sequence":"additional","affiliation":[{"name":"Department of Haematology Gunma University Graduate School of Medicine Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Irisawa","sequence":"additional","affiliation":[{"name":"Division of Haematology Gunma Prefectural Cancer Centre Ohta Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makiko","family":"Takizawa","sequence":"additional","affiliation":[{"name":"Department of Haematology Gunma University Graduate School of Medicine Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Saitoh","sequence":"additional","affiliation":[{"name":"Department of Laboratory Sciences Gunma University Graduate School of Health Science Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayoko","family":"Murayama","sequence":"additional","affiliation":[{"name":"Division of Haematology Gunma Prefectural Cancer Centre Ohta Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morio","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Division of Haematology National Hospital Organization Shibukawa Medical Centre Shibukawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3753-9862","authenticated-orcid":false,"given":"Hiroshi","family":"Handa","sequence":"additional","affiliation":[{"name":"Department of Haematology Gunma University Graduate School of Medicine Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko","family":"Hirato","sequence":"additional","affiliation":[{"name":"Department of Pathology Gunma University Hospital Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Kojima","sequence":"additional","affiliation":[{"name":"Department of Anatomic and Diagnostic Pathology Dokkyo University School of Medicine Mibu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirokazu","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Laboratory Sciences Gunma University Graduate School of Health Science Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norifumi","family":"Tsukamoto","sequence":"additional","affiliation":[{"name":"Oncology Centre Gunma University Hospital Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,12]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_8_2_1","DOI":"10.1007\/s00432-006-0188-3"},{"doi-asserted-by":"publisher","key":"e_1_2_8_3_1","DOI":"10.1007\/978-1-4612-1694-0_15"},{"doi-asserted-by":"publisher","key":"e_1_2_8_4_1","DOI":"10.1182\/blood-2013-05-500595"},{"doi-asserted-by":"publisher","key":"e_1_2_8_5_1","DOI":"10.1182\/blood-2008-02-140616"},{"key":"e_1_2_8_6_1","first-page":"783","article-title":"Prognosis of follicular lymphoma: a predictive model based on a retrospective analysis of 987 cases. 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