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The relevance of the inflammatory microenvironment in <jats:styled-content style=\"fixed-case\">cHL<\/jats:styled-content> prompted us to investigate the key immunomodulator myeloid dendritic cells type\u20101 (<jats:styled-content style=\"fixed-case\">mDC<\/jats:styled-content>1), type\u20102 (<jats:styled-content style=\"fixed-case\">mDC<\/jats:styled-content>2) and plasmacytoid dendritic cells (<jats:styled-content style=\"fixed-case\">pDC<\/jats:styled-content>). Blood <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content> levels were assessed in 52 newly diagnosed patients through multiparametric flow\u2010cytometry. All but two patients received <jats:styled-content style=\"fixed-case\">ABVD<\/jats:styled-content> regimen (doxorubicin, bleomycin, vinblastine, dacarbazine). The median counts of all <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content> subsets were lower in <jats:styled-content style=\"fixed-case\">cHL<\/jats:styled-content> patients than in healthy controls (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001). Median <jats:styled-content style=\"fixed-case\">mDC<\/jats:styled-content> counts were inferior for the advanced vs early stage patients for both <jats:styled-content style=\"fixed-case\">mDC<\/jats:styled-content>1s and <jats:styled-content style=\"fixed-case\">mDC<\/jats:styled-content>2s (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7008; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b70007 respectively). Also, median <jats:styled-content style=\"fixed-case\">mDC<\/jats:styled-content>2 counts were reduced in case of bulky (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b70004) and extra\u2010nodal (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7046) disease. Patients with B symptoms had lower levels for <jats:styled-content style=\"fixed-case\">mDC<\/jats:styled-content>1s (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7046), <jats:styled-content style=\"fixed-case\">mDC<\/jats:styled-content>2s (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7009) and <jats:styled-content style=\"fixed-case\">pDC<\/jats:styled-content>s (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7040). All the <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content> subtypes increased at the end of treatment in 26 patients (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001): 4\u00b76\u2010fold for <jats:styled-content style=\"fixed-case\">mDC<\/jats:styled-content>1, 2\u00b74\u2010fold for <jats:styled-content style=\"fixed-case\">mDC<\/jats:styled-content>2, 4\u00b75\u2010fold for <jats:styled-content style=\"fixed-case\">pDC<\/jats:styled-content> and aligned <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>s subsets with the reference frequencies and the interquartile ranges of the controls. In conclusion, <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>s may contribute to the disturbed immunological interplay typical of <jats:styled-content style=\"fixed-case\">cHL<\/jats:styled-content>, prompting a further evaluation of their value as a potential new biomarker.<\/jats:p>","DOI":"10.1111\/bjh.15676","type":"journal-article","created":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T02:35:31Z","timestamp":1542162931000},"page":"594-604","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Circulating dendritic cells deficiencies as a new biomarker in classical Hodgkin lymphoma"],"prefix":"10.1111","volume":"184","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5613-9149","authenticated-orcid":false,"given":"Domenico","family":"Galati","sequence":"first","affiliation":[{"name":"Haematology\u2010Oncology and Stem\u2010Cell Transplantation Unit Department of Haematology and Innovative Therapies Istituto Nazionale Tumori \u2013 IRCCS \u2013 Fondazione G. 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