{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T05:26:04Z","timestamp":1781501164686,"version":"3.54.1"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,11,22]],"date-time":"2018-11-22T00:00:00Z","timestamp":1542844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Allogeneic haematopoietic stem cell transplant (allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>) offers potentially curative therapy for patients with relapsed\/refractory lymphoid malignancies. Reduced\u2010intensity conditioning (<jats:styled-content style=\"fixed-case\">RIC<\/jats:styled-content>) with Alemtuzumab reduces transplant\u2010related mortality and graft\u2010versus\u2010host disease (Gv<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>), but may be associated with increased risk of relapse. With the aim of studying the effect of <jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content> and donor lymphocyte infusions (<jats:styled-content style=\"fixed-case\">DLI<\/jats:styled-content>) on relapse, we performed a retrospective study of 288 patients (57% non\u2010Hodgkin lymphoma, 24% Hodgkin lymphoma and 19% chronic lymphocytic leukaemia; 58% were relapsed\/refractory) who underwent <jats:styled-content style=\"fixed-case\">RIC<\/jats:styled-content>\u2010Alemtuzumab\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> between 2000 and 2012. Median follow\u2010up time for survivors was 64\u00a0months. Five\u2010year overall survival, relapse incidence, Gv<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>\/relapse\u2010free survival and non\u2010relapse mortality were 47%, 33%, 37% and 28% respectively. Cumulative incidence of grade <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> acute and extensive chronic Gv<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> was 22% and 21% at 100\u00a0days and 5\u00a0years respectively. On multivariate analysis, presence of Gv<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b703) and unrelated donor type (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b703) were protective of relapse. 62\/288 patients received <jats:styled-content style=\"fixed-case\">DLI<\/jats:styled-content> for either mixed donor chimerism (prophylactic <jats:styled-content style=\"fixed-case\">DLI<\/jats:styled-content>,<jats:italic> n<\/jats:italic>\u00a0=\u00a037) or clinical relapse (therapeutic <jats:styled-content style=\"fixed-case\">DLI<\/jats:styled-content>,<jats:italic> n<\/jats:italic>\u00a0=\u00a025). Prophylactic and therapeutic <jats:styled-content style=\"fixed-case\">DLI<\/jats:styled-content> successfully converted the patient to full or stable mixed donor chimerism in 78% and 56% of patients respectively. These data demonstrate good long\u2010term outcomes and support the concept of the graft\u2010vs\u2010lymphoma effect as a key protective factor against relapse following <jats:styled-content style=\"fixed-case\">RIC<\/jats:styled-content>\u2010Alemtuzumab allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> for patients with mature lymphoid malignancies.<\/jats:p>","DOI":"10.1111\/bjh.15685","type":"journal-article","created":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T06:40:19Z","timestamp":1542955219000},"page":"547-557","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Impact of graft\u2010versus\u2010lymphoma effect on outcomes after reduced intensity conditioned\u2010alemtuzumab allogeneic haematopoietic stem cell transplantation for patients with mature lymphoid malignancies"],"prefix":"10.1111","volume":"184","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4028-3733","authenticated-orcid":false,"given":"Charlotte K.","family":"Brierley","sequence":"first","affiliation":[{"name":"Department of Haematology Oxford University Hospitals NHS Foundation Trust Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca M.","family":"Jones","sequence":"additional","affiliation":[{"name":"Centre for Clinical Haematology University Hospitals Birmingham NHS Foundation Trust Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharine","family":"Hanlon","sequence":"additional","affiliation":[{"name":"Department of Haematology Beatson West of Scotland Cancer Centre Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andy J.","family":"Peniket","sequence":"additional","affiliation":[{"name":"Department of Haematology Oxford University Hospitals NHS Foundation Trust Oxford 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