{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:09:16Z","timestamp":1787242156808,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T00:00:00Z","timestamp":1543363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Chronic venous disease (\n                    <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>\n                    ) represents a significant healthcare burden. Thrombophilia is proposed as a risk factor, particularly for post\u2010thrombotic\n                    <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>\n                    . A systematic review was performed to determine the relationship between thrombophilia and non\u2010thrombotic\n                    <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>\n                    .\n                    <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>\n                    <jats:sup>\u00ae<\/jats:sup>\n                    and Embase\n                    <jats:sup>\u00ae<\/jats:sup>\n                    databases were searched from 1946 up to March 2018. Case\u2010control studies, cohort studies or randomised clinical trials reporting on thrombophilias in non\u2010thrombotic lower limb\n                    <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>\n                    in adult patients were included. Non\u2010English and post\u2010thrombotic syndrome studies were excluded. Study selection and data extraction were performed by two reviewers. Fifteen studies were included, reporting on 916 cases and 1261 controls. Studies largely focused on venous ulceration and investigated multiple haemostatic factors. An association between thrombophilia and non\u2010thrombotic\n                    <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>\n                    was identified, with greater prevalence and factor concentration alteration reported in patients compared to controls. Concomitant thrombophilia presence was associated with earlier\n                    <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>\n                    onset. Relationship strength varied, with commoner aetiologies showing clearer correlation than rarer ones. Thrombophilia is associated with non\u2010thrombotic\n                    <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>\n                    but the mechanism is unclear and causation cannot be determined. Future research should focus on prospective studies with larger populations and identify adjunct therapies targeting thrombophilia.\n                  <\/jats:p>","DOI":"10.1111\/bjh.15692","type":"journal-article","created":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T21:01:52Z","timestamp":1543438912000},"page":"703-716","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Thrombophilia in non\u2010thrombotic chronic venous disease of the lower limb \u2013 a systematic review"],"prefix":"10.1111","volume":"183","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5789-0353","authenticated-orcid":false,"given":"Matthew K. 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