{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T23:51:18Z","timestamp":1769817078402,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T00:00:00Z","timestamp":1544572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006436","name":"Celgene","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006436","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Combined lenalidomide and dexamethasone is a standard\u2010of\u2010care therapy for the treatment of older adults with multiple myeloma. Lenalidomide monotherapy has not been evaluated in newly diagnosed myeloma patients. We conducted a phase <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> study, evaluating a response\u2010adapted therapy for older adults newly diagnosed with multiple myeloma without high\u2010risk features who were ineligible for high\u2010dose therapy and stem cell transplant. Patients were started on single\u2010agent lenalidomide, and low\u2010dose dexamethasone was added in the event of progressive disease, in a response\u2010adapted approach. The primary endpoint was progression\u2010free survival (<jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content>), and the International Myeloma Working Group's uniform response criteria were used to assess response and progression. Twenty\u2010seven patients were enrolled, and 20 (74%) experienced a partial response or better to this response\u2010adapted therapy. After a median follow\u2010up of 69\u00a0months, the median PFS was 36\u00a0months [95% confidence interval (CI), 29\u00b78 to not reached], and the median overall survival was 65\u00a0months (95% CI, 35\u00b73 to not reached). Grade 3\/4 adverse events were mainly haematological in nature. This response\u2010adapted therapy in this patient population is feasible and results in durable responses that compare favourably with concurrent lenalidomide and dexamethasone. These results should be validated in prospective studies.<\/jats:p>","DOI":"10.1111\/bjh.15700","type":"journal-article","created":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T08:40:05Z","timestamp":1544604005000},"page":"735-743","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Lenalidomide\u2010based response\u2010adapted therapy for older adults without high risk myeloma"],"prefix":"10.1111","volume":"184","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4538-4733","authenticated-orcid":false,"given":"Rachid","family":"Baz","sequence":"first","affiliation":[{"name":"Department of Malignant Haematology H. Lee Moffitt Cancer Center and Research Institute Tampa FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syeda Mahrukh Hussnain","family":"Naqvi","sequence":"additional","affiliation":[{"name":"Department of Biostatistics H. Lee Moffitt Cancer Center and Research Institute Tampa FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae\u2010Hoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Hematology Gil Medical Center Gachon University College of Medicine Incheon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Brayer","sequence":"additional","affiliation":[{"name":"Department of Malignant Haematology H. Lee Moffitt Cancer Center and Research Institute Tampa FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Hillgruber","sequence":"additional","affiliation":[{"name":"Department of Malignant Haematology H. Lee Moffitt Cancer Center and Research Institute Tampa FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brooke L.","family":"Fridley","sequence":"additional","affiliation":[{"name":"Department of Biostatistics H. 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