{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T22:05:58Z","timestamp":1771020358334,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,2]],"date-time":"2018-12-02T00:00:00Z","timestamp":1543708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Plasma cells are important prognostic actors in different malignancies. The tumour microenvironmental composition in classic Hodgkin lymphoma (cHL) is a major prognostic key element; however, clinicopathological studies regarding plasma cells in cHL are lacking. The aim of this study was to investigate CD138+ (also termed SDC1+) plasma cell and IgG4 producing (IgG4+) plasma cells infiltration in the microenvironment of cHL. Immunohistochemistry with anti\u2010CD138 and IgG4 antibodies was performed on diagnostic tumour biopsies from 124 patients with cHL, on tissue micro array (TMA). In 120 cases, CD138+ plasma cell\u2010infiltration was associated with the presence of B\u2010symptoms (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7028) and advanced stage, IIB\u2010IVB (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7009). In multivariate analysis, CD138+ plasma cells correlated with eosinophil infiltration (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7013). The subgroup of IgG4+ plasma cells was analysed in 122 cases and only correlated to CD138+ plasma cells (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7004). Patients with high proportion of tumour infiltrating CD138+ plasma cells (defined as \u226510%), had a more inferior event\u2010free survival (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7007) and overall survival (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7004) than patients with a low proportion of infiltrating CD138+ plasma cells (&lt;10%), although significance was not maintained in multivariate analysis. In summary, a high proportion of tumour\u2010associated plasma cells in cHL reflect an important component in the microenvironment of cHL.<\/jats:p>","DOI":"10.1111\/bjh.15703","type":"journal-article","created":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T02:35:31Z","timestamp":1543804531000},"page":"192-201","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["High tumour plasma cell infiltration reflects an important microenvironmental component in classic Hodgkin lymphoma linked to presence of B\u2010symptoms"],"prefix":"10.1111","volume":"184","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3393-1106","authenticated-orcid":false,"given":"Alex R.","family":"Gholiha","sequence":"first","affiliation":[{"name":"Experimental and Clinical Oncology Department of Immunology, Genetics and Pathology Uppsala University Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0226-5681","authenticated-orcid":false,"given":"Peter","family":"Hollander","sequence":"additional","affiliation":[{"name":"Section\u00a0of Pathology Department of Immunology, Genetics and Pathology Uppsala University Uppsala University Hospital Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustaf","family":"Hedstrom","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Oncology Department of Immunology, Genetics and Pathology Uppsala University Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christer","family":"Sundstrom","sequence":"additional","affiliation":[{"name":"Section\u00a0of Pathology Department of Immunology, Genetics and Pathology Uppsala University Uppsala University Hospital Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Molin","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Oncology Department of Immunology, Genetics and Pathology Uppsala University Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin E.","family":"Smedby","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology Department of Medicine Solna Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Hjalgrim","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology Department of Medicine Solna Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"Glimelius","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Oncology Department of Immunology, Genetics and Pathology Uppsala University 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