{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T21:51:56Z","timestamp":1785448316028,"version":"3.56.0"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T00:00:00Z","timestamp":1544486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01 CA23766"],"award-info":[{"award-number":["P01 CA23766"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:italic><jats:styled-content style=\"fixed-case\">TP<\/jats:styled-content>53<\/jats:italic> alterations portend extremely poor prognosis in patients with mantle cell lymphoma treated with standard treatment modalities. We reviewed outcomes of 42 patients with available <jats:italic><jats:styled-content style=\"fixed-case\">TP<\/jats:styled-content>53<\/jats:italic> status who had received a reduced\u2010intensity or non\u2010myeloablative allogeneic haematopoietic cell transplant at our institution. We demonstrated a 2\u2010year overall survival and progression\u2010free survival of 78% [95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) 60\u201388] and 61% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 43\u201375), respectively. The 2\u2010year cumulative incidences of relapse and non\u2010relapse mortality were 19% and 20%, respectively. Importantly, there is no significant difference among patients with and without <jats:italic><jats:styled-content style=\"fixed-case\">TP<\/jats:styled-content>53<\/jats:italic> alterations, suggesting for the first time a beneficial treatment modality for these high\u2010risk patients.<\/jats:p>","DOI":"10.1111\/bjh.15721","type":"journal-article","created":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T12:13:00Z","timestamp":1544530380000},"page":"1006-1010","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Allogeneic haematopoietic cell transplantation impacts on outcomes of mantle cell lymphoma with <i><scp>TP<\/scp>53<\/i> alterations"],"prefix":"10.1111","volume":"184","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0834-7880","authenticated-orcid":false,"given":"Richard J.","family":"Lin","sequence":"first","affiliation":[{"name":"Adult BMT Service Memorial Sloan Kettering Cancer Center New York NY 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