{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:07:04Z","timestamp":1791900424150,"version":"4.3.4"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,12,28]],"date-time":"2018-12-28T00:00:00Z","timestamp":1545955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["MFAG2016"],"award-info":[{"award-number":["MFAG2016"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    The scenario of paediatric acute myeloid leukaemia (\n                    <jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>\n                    ), particularly non\u2010Down syndrome acute megakaryoblastic leukaemia (non\u2010\n                    <jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content>\n                    \u2010\n                    <jats:styled-content style=\"fixed-case\">AMKL<\/jats:styled-content>\n                    ), has been recently revolutionized by the advent of large\u2010scale, genomic sequencing technologies. In this changing landscape, a significantly relevant discovery has been represented by the identification of the\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">CBFA<\/jats:styled-content>\n                      2T3\n                    <\/jats:italic>\n                    \u2010\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">GLIS<\/jats:styled-content>\n                      2\n                    <\/jats:italic>\n                    fusion gene, which is the result of a cryptic inversion of chromosome 16. It is the most frequent chimeric oncogene identified to date in non\u2010\n                    <jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content>\n                    \u2010\n                    <jats:styled-content style=\"fixed-case\">AMKL<\/jats:styled-content>\n                    , although it seems not to be exclusively restricted to the French\u2010American\u2010British M7 subgroup. The\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">CBFA<\/jats:styled-content>\n                      2T3\n                    <\/jats:italic>\n                    \u2010\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">GLIS<\/jats:styled-content>\n                      2\n                    <\/jats:italic>\n                    fusion gene characterizes a subtype of leukaemia that is specific to paediatrics, having never been identified in adults. It characterizes an extremely aggressive leukaemia, as the presence of this fusion is associated with a grim outcome in almost all of the case series reported, with overall survival rates ranging between 15% and 30%. Although the molecular basis that underlies this leukaemia subtype is still far from being completely elucidated, unique functional properties induced by\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">CBFA<\/jats:styled-content>\n                      2T3\u2010\n                      <jats:styled-content style=\"fixed-case\">GLIS<\/jats:styled-content>\n                      2\n                    <\/jats:italic>\n                    in the leukaemogenesis driving process have been recently identified. We here review the peculiarities of\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">CBFA<\/jats:styled-content>\n                      2T3\n                    <\/jats:italic>\n                    \u2010\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">GLIS<\/jats:styled-content>\n                      2\n                    <\/jats:italic>\n                    \u2010positive\n                    <jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>\n                    , describing its intriguing clinical and biological behaviour and providing some challenging targeting opportunities.\n                  <\/jats:p>","DOI":"10.1111\/bjh.15725","type":"journal-article","created":{"date-parts":[[2018,12,28]],"date-time":"2018-12-28T06:04:34Z","timestamp":1545977074000},"page":"337-347","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["CBFA2T3\u2010GLIS2\u2010positive acute myeloid leukaemia. A peculiar paediatric entity"],"prefix":"10.1111","volume":"184","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1264-057X","authenticated-orcid":false,"given":"Riccardo","family":"Masetti","sequence":"first","affiliation":[{"name":"Department of Paediatrics \u201cLalla Ser\u00e0gnoli\u201d, Haematology\u2010Oncology Unit University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5428-6716","authenticated-orcid":false,"given":"Salvatore N.","family":"Bertuccio","sequence":"additional","affiliation":[{"name":"Department of Paediatrics \u201cLalla Ser\u00e0gnoli\u201d, Haematology\u2010Oncology Unit University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Pession","sequence":"additional","affiliation":[{"name":"Department of Paediatrics \u201cLalla Ser\u00e0gnoli\u201d, Haematology\u2010Oncology Unit University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7976-3654","authenticated-orcid":false,"given":"Franco","family":"Locatelli","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haematology\u2010Oncology and Cell and Gene Therapy IRCCS Ospedale Pediatrico Bambino Ges\u00f9, Rome Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,28]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.2046"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng2072"},{"key":"e_1_2_15_4_1","first-page":"103","article-title":"The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age\u2010specific mutational interactions","volume":"24","author":"Bolouri H.","year":"2018","journal-title":"Nature 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