{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:15:45Z","timestamp":1789017345510,"version":"build-2803163510"},"reference-count":72,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,12,28]],"date-time":"2018-12-28T00:00:00Z","timestamp":1545955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006751","name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006751","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Advances in the development of effective and safe treatments for haemophilia over the last 50\u00a0years have resulted in a significant increase in the life expectancy of persons with haemophilia (\n                    <jats:styled-content style=\"fixed-case\">PWH<\/jats:styled-content>\n                    ). The management of this new cohort of middle\u2010aged and elderly\n                    <jats:styled-content style=\"fixed-case\">PWH<\/jats:styled-content>\n                    is challenging because of the opposing risks of haemophilia and age\u2010related cardiovascular disease and malignancy. Furthermore, this cohort of ageing\n                    <jats:styled-content style=\"fixed-case\">PWH<\/jats:styled-content>\n                    has the additional comorbidities of human immunodeficiency virus\/hepatitis C and chronic haemophilic arthropathy. This article reviews the prevalence, underlying mechanisms and treatment strategies for managing these comorbidities. International collaboration is essential for registry data and further prospective trials to inform optimal evidence\u2010based management for this rare disorder in the future.\n                  <\/jats:p>","DOI":"10.1111\/bjh.15745","type":"journal-article","created":{"date-parts":[[2018,12,28]],"date-time":"2018-12-28T03:53:46Z","timestamp":1545969226000},"page":"712-720","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Haemophilia and ageing"],"prefix":"10.1111","volume":"184","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0402-0802","authenticated-orcid":false,"given":"Susan","family":"Shapiro","sequence":"first","affiliation":[{"name":"Oxford Haemophilia and Thrombosis Centre NIHR Oxford Biomedical Research Centre Oxford University Hospitals NHS Foundation Trust Oxford 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