{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:16:35Z","timestamp":1789017395708,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T00:00:00Z","timestamp":1547078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Israeli Society of Pediatric Haemato-Oncology"},{"name":"Amutat Haim"},{"DOI":"10.13039\/501100003975","name":"The Israeli Cancer Association","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003975","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>This study investigated the prevalence of inherited thrombophilia, risk of venous thromboembolism (<jats:styled-content style=\"fixed-case\">VTE<\/jats:styled-content>) and benefit of low molecular weight heparin prophylaxis in 476 Israeli children with acute lymphoblastic leukaemia (<jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>) treated between 2004 and 2016. Thrombophilia was found in 15\u00b75%. Arab children had a higher prevalence of <jats:italic>F5<\/jats:italic> R506Q (factor V Leiden) than Jewish children (19\u00b74% vs. 2\u00b79%, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b701). Patients with thrombophilia had higher <jats:styled-content style=\"fixed-case\">VTE<\/jats:styled-content> rates <jats:styled-content style=\"fixed-case\">VTE<\/jats:styled-content> (26\u00b75% vs. 5\u00b76%, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b7001). None of the thrombophilic children given prophylaxis had severe <jats:styled-content style=\"fixed-case\">VTE<\/jats:styled-content>. Routine evaluation for inherited thrombophilia followed by thromboprophylaxis when findings are positive may benefit at\u2010risk patients with <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/bjh.15752","type":"journal-article","created":{"date-parts":[[2019,1,11]],"date-time":"2019-01-11T09:15:46Z","timestamp":1547198146000},"page":"994-998","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Thrombophilia screening and thromboprophylaxis may benefit specific ethnic subgroups with paediatric acute lymphoblastic leukaemia"],"prefix":"10.1111","volume":"184","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3994-0556","authenticated-orcid":false,"given":"Shlomit","family":"Barzilai\u2010Birenboim","sequence":"first","affiliation":[{"name":"Department of Paediatric Haematology and Oncology Schneider Children's Medical Centre of Israel, Petach Tivka Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nira","family":"Arad\u2010Cohen","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haematology\u2013Oncology Ruth Rappaport Children's Hospital Rambam Health Care Campus Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronit","family":"Nirel","sequence":"additional","affiliation":[{"name":"Department of Statistics Hebrew University Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galia","family":"Avrahami","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haematology and Oncology Schneider Children's Medical Centre of Israel, Petach Tivka Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Harlev","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haematology\u2013Oncology Ruth Rappaport Children's Hospital Rambam Health Care Campus Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil","family":"Gilad","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haematology and Oncology Schneider Children's Medical Centre of Israel, Petach Tivka Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronit","family":"Elhasid","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haemato\u2010Oncology Tel Aviv Medical Centre Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shai","family":"Izraeli","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haematology and Oncology Schneider Children's Medical Centre of Israel, Petach Tivka Sackler Faculty of Medicine Tel Aviv University Tel Aviv 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