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For most patients, this means treatment with multiple lines of anti\u2010myeloma therapy and a life with disease\u2010 and treatment\u2010related symptoms and complications. Health\u2010related quality of life (HRQoL) issues play an important role in treatment decision\u2010making. Methodological challenges in longitudinal HRQoL measurements and analyses have been identified, including non\u2010responses (NR) to scheduled questionnaires. Publications were identified for inclusion in a systematic review of longitudinal HRQoL studies in MM, focussing on methodological aspects of HRQoL measurement and analysis. Diversity in timing of HRQoL data collection and applied statistical methods were noted. We observed a high rate of NR, but the impact of NR was investigated in only 8\/23 studies. Thus, evidence\u2010based knowledge of HRQoL in patients with MM is compromised. To improve quality of HRQoL results and their implementation in daily practice, future studies should follow established guidelines.<\/jats:p>","DOI":"10.1111\/bjh.15759","type":"journal-article","created":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T02:57:43Z","timestamp":1547780263000},"page":"11-24","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Methodological aspects of health\u2010related quality of life measurement and analysis in patients with multiple myeloma"],"prefix":"10.1111","volume":"185","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2083-3870","authenticated-orcid":false,"given":"Lene Kongsgaard","family":"Nielsen","sequence":"first","affiliation":[{"name":"Quality of Life Research Center Department of Haematology Odense University Hospital Odense Denmark"},{"name":"The Academy of Geriatric Cancer Research (AgeCare) Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Abildgaard","sequence":"additional","affiliation":[{"name":"Quality of Life Research Center Department of Haematology Odense University Hospital Odense Denmark"},{"name":"The Academy of Geriatric Cancer Research (AgeCare) Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Jarden","sequence":"additional","affiliation":[{"name":"Department of Haematology Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias Wirenfeld","family":"Klausen","sequence":"additional","affiliation":[{"name":"Department of Haematology Herlev Hospital Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/85.5.365"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2016.03.011"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-85772-3_2"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0962280213476378"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e8668"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402551"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-018850"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2012.11.003"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.324.7346.1156"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30510-1"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1740774518795637"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-010-9793-3"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-011-9848-0"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu489"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.879"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.21903"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-7625.2007.00441.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2012.01788.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.120121"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2012.074534"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2013.847933"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2014.06.016"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.0824"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.10.017"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29489"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-03-737403"},{"key":"e_1_2_7_28_1","first-page":"1855","article-title":"Autologous stem cell transplantation improves quality of life in economically challenged, Brazilian multiple myeloma patients","volume":"66","author":"Etto L.Y.","year":"2011","journal-title":"Clinics (Sao Paulo)"},{"key":"e_1_2_7_29_1","volume-title":"Guidelines Patient\u2010Reported Outcomes in Hematology","author":"European Hematology Association Scientific Working Group","year":"2013"},{"key":"e_1_2_7_30_1","volume-title":"Appendix\u00a02 to the Guideline on the Evaluation of Anticancer Medicinal Products in Man. 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