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This study measured the prevalence, incidence and clinical outcomes associated with T2<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> in a large <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> population of commercially\u2010insured adults aged \u226520\u00a0years with <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> between 2009 and 2014. Among 7070 patients with <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>, the mean age (median) was 39 (37) years and 60\u00b78% were female. The standardized prevalence of T2<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> among patients with <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> showed a modest increase, from 15\u00b77% to 16\u00b75% (<jats:italic>P<\/jats:italic> trend\u00a0=\u00a00\u00b7026), and was comparable to African\u2010American respondents to the National Health and Nutrition Examination Survey (18\u00b72%). Over 17\u00a0024 person\u2010years, the crude incidence rate for T2<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> was 25\u00b74 per 1000 person\u2010years. Incident T2<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> was associated with comorbid hypertension (hazard ratio [<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>]\u00a0=\u00a01\u00b745, 95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] 1\u00b714\u20131\u00b783), and dyslipidaemia (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u00a0=\u00a01\u00b743, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1\u00b704\u20131\u00b796). Compared to <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> patients without T2<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>, more <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> patients with T2<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> had diagnoses of nephropathy (28\u00b70% vs. 9\u00b75%; <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b7001), neuropathy (17\u00b77% vs. 5\u00b72%; <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b7001) and stroke (24\u00b71% vs. 9\u00b72%; <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b7001). Prevalence of T2<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> patients is similar to the general African American population with an increasing trend in recent years. These trends support routine screening for T2<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> in aging patients with <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>, especially those with comorbid hypertension and\/or dyslipidaemia.<\/jats:p>","DOI":"10.1111\/bjh.15773","type":"journal-article","created":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T02:44:10Z","timestamp":1549248250000},"page":"116-127","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Similar burden of type 2 diabetes among adult patients with sickle cell disease relative to African Americans in the U.S. population: a six\u2010year population\u2010based cohort analysis"],"prefix":"10.1111","volume":"185","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2590-8667","authenticated-orcid":false,"given":"Jifang","family":"Zhou","sequence":"first","affiliation":[{"name":"Center for Pharmacoepidemiology and Pharmacoeconomic Research University of Illinois at Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0662-006X","authenticated-orcid":false,"given":"Jin","family":"Han","sequence":"additional","affiliation":[{"name":"Center for Pharmacoepidemiology and Pharmacoeconomic Research University of Illinois at Chicago Chicago IL USA"},{"name":"Department of Pharmacy Practice College of Pharmacy University of Illinois at Chicago Chicago IL USA"},{"name":"Division of Hematology &amp; Oncology Department of Medicine, Comprehensive Sickle Cell Center University of Illinois at Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith A.","family":"Nutescu","sequence":"additional","affiliation":[{"name":"Center for Pharmacoepidemiology and Pharmacoeconomic Research University of Illinois at Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William L.","family":"Galanter","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice College of Pharmacy University of Illinois at Chicago Chicago IL USA"},{"name":"Department of Medicine Section\u00a0of Academic Internal Medicine &amp; Geriatrics University of Illinois at Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surrey M.","family":"Walton","sequence":"additional","affiliation":[{"name":"Center for Pharmacoepidemiology and Pharmacoeconomic Research University of Illinois at Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor R.","family":"Gordeuk","sequence":"additional","affiliation":[{"name":"Division of Hematology &amp; Oncology Department of Medicine, Comprehensive Sickle Cell Center University of Illinois at Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8584-4194","authenticated-orcid":false,"given":"Santosh L.","family":"Saraf","sequence":"additional","affiliation":[{"name":"Division of Hematology &amp; Oncology Department of Medicine, Comprehensive Sickle Cell Center University of Illinois at Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7744-3518","authenticated-orcid":false,"given":"Gregory S.","family":"Calip","sequence":"additional","affiliation":[{"name":"Center for Pharmacoepidemiology and Pharmacoeconomic Research University of Illinois at Chicago Chicago IL USA"},{"name":"Division of Public Health Sciences Epidemiology Program Fred Hutchinson Cancer Research Center Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1056-8727(02)00190-3"},{"key":"e_1_2_7_3_1","volume-title":"Health Research Data for the Real World: The MarketScan Databases","author":"Adamson D.M.","year":"2008"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2307\/2685469"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/03630269.2014.927363"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-S062"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyr213"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2009.10.002"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-125-3-199608010-00011"},{"key":"e_1_2_7_10_1","unstructured":"CDC. 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