{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:50:20Z","timestamp":1791561020159,"version":"4.3.4"},"reference-count":85,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,2,10]],"date-time":"2019-02-10T00:00:00Z","timestamp":1549756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>In high\u2010income countries, more than 90% of children with mature B\u2010cell lymphomas are cured with frontline therapy. However, cure requires prompt and correct diagnosis, careful risk stratification, very intense chemotherapy and meticulous supportive care, together with logistical support for patients who live far from the cancer centre or face financial barriers to receiving care. In low\u2010 and middle\u2010income countries (<jats:styled-content style=\"fixed-case\">LMIC<\/jats:styled-content>), cure rates range from 20% to 70% because of lack of diagnosis, misdiagnosis, abandonment of treatment, toxic death and excess relapse with reduced\u2010intensity regimens. Fortunately, a wide range of successful interventions in <jats:styled-content style=\"fixed-case\">LMIC<\/jats:styled-content> have reduced these causes of avoidable treatment failure. Public awareness campaigns have led to societal awareness of childhood cancer; telepathology has improved diagnosis, even in remote areas; subsidized chemotherapy, transportation, housing and food have reduced abandonment; and hand hygiene, nurse training programmes and health system improvements have reduced toxic death. These interventions can be deployed everywhere and at low cost, so are highly scalable. Children and adolescents with Burkitt lymphoma can be cured in all countries by making a timely correct diagnosis, applying protocols adapted to the local context, preventing abandonment of therapy and avoiding toxic death. Reducing these causes of treatment failure is feasible and highly cost\u2010effective everywhere.<\/jats:p>","DOI":"10.1111\/bjh.15785","type":"journal-article","created":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T01:43:56Z","timestamp":1549849436000},"page":"1125-1135","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Optimizing outcomes for children with non\u2010Hodgkin lymphoma in low\u2010 and middle\u2010income countries by early correct diagnosis, reducing toxic death and preventing abandonment"],"prefix":"10.1111","volume":"185","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9375-9336","authenticated-orcid":false,"given":"Guillermo","family":"Chantada","sequence":"first","affiliation":[{"name":"Hospital Universitario Austral Pilar Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1363-5331","authenticated-orcid":false,"given":"Catherine G.","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Global Pediatric Medicine St. Jude Children's Research Hospital Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2244-1686","authenticated-orcid":false,"given":"Scott C.","family":"Howard","sequence":"additional","affiliation":[{"name":"University of Tennessee Health Science Center Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20116"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-7563.2009.01264.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11523-010-0161-6"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)33326-3"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26560"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.53.0808"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/0189-6725.48566"},{"key":"e_1_2_8_9_1","first-page":"1397","article-title":"Epstein\u2010Barr virus and Burkitt lymphoma","volume":"60","author":"Brady G.","year":"2007","journal-title":"Journal of Clinical Pathology"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30170"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08143.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15491"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3181e90017"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25698"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e31826226b1"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199705)28:5<333::AID-MPO2>3.0.CO;2-I"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JGO.18.00150"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25612"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.29271\/jcpsp.2018.01.48"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2012.03.006"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0135230"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24848"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043639"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/10245332.2018.1510087"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13040"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-04-844472"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14030"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2013.03.024"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1596\/978-1-4648-0349-9_ch7"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21452"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.3109\/08880018.2011.644881"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24407"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.7196\/SAMJ.2018.v108i2.12441"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20245"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.04.020"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21003"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20989"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0904569"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2015-0164"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26879"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30123-2"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22032"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24501"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep03741"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.4103\/2224-3151.239414"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200407000-00014"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26016"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers10060177"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3182580bea"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.23050"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjpo-2017-000149"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.59.5827"},{"key":"e_1_2_8_53_1","unstructured":"Ministerio de Salud y Protecci\u00f3n Social \u2013 Colciencias. (2013)Gu\u00eda de Pr\u00e1ctica Cl\u00ednica para la detecci\u00f3n oportuna diagn\u00f3stico tratamiento y seguimiento de Linfoma de Hodgkin y Linfoma No Hodgkin Aguda en ni\u00f1os ni\u00f1as y adolescentes. Gu\u00eda No. 10.http:\/\/www.iets.org.co\/reportes-iets\/Documentacin%20Reportes\/Gu%C3%ADa.Completa.Linfomas.2013.pdf"},{"key":"e_1_2_8_54_1","unstructured":"Ministry of Health and Sanitation Sierra Leone. (2010)Basic Package of Essential Health Services for Sierra Leone \u2010 2010. Government of Sierra Leone Freetown Sierra Leone.http:\/\/www.ministerial-leadership.org\/sites\/default\/files\/resources_and_tools\/NHSSP%202010-2015.pdf"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22905"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70128-0"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.3571"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002505"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08772.x"},{"key":"e_1_2_8_60_1","first-page":"1","article-title":"Cost of treating pediatric cancer at the Butaro cancer center of excellence in Rwanda","volume":"4","author":"Neal C.","year":"2018","journal-title":"Journal of Global Oncology"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.11.3370"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-07-036673"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0929-693X(15)30034-8"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27621"},{"key":"e_1_2_8_65_1","first-page":"1","article-title":"Access to essential medicines in 195 countries: a human rights approach to sustainable development","author":"Perehudoff S.K.","year":"2018","journal-title":"Global Public Health"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14044"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26590"},{"key":"e_1_2_8_68_1","first-page":"3294","article-title":"Improved treatment results in childhood B\u2010cell neoplasms with tailored intensification of therapy: a report of the Berlin\u2010Frankfurt\u2010Munster Group Trial NHL\u2010BFM 90","volume":"94","author":"Reiter A.","year":"1999","journal-title":"Blood"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12992-018-0421-2"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25557"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e31829d4900"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1093\/trstmh\/trt069"},{"key":"e_1_2_8_73_1","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1182\/blood.V128.22.1858.1858","article-title":"Improved outcome and decreased morbidity and mortality rates of B\u2010cell malignancies with less intensive chemotherapy induction: experience in a single Institution","volume":"128","author":"Sanchez La Rosa C.G.","year":"2016","journal-title":"Blood"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13986"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-9378-9-19"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30186-9"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25510"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2006.00735.x"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70450-9"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-017-2318-0"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22746"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27399"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2015.158"},{"key":"e_1_2_8_84_1","first-page":"2215","article-title":"Childhood cancer incidence and survival 2003\u20102005, Thailand: study from the Thai Pediatric Oncology Group","volume":"12","author":"Wiangnon S.","year":"2011","journal-title":"Asian Pacific Journal of Cancer Prevention"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-03-0973"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.7196\/SAMJ.6365"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjh.15785","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.15785","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.15785","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.15785","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T21:25:22Z","timestamp":1694381122000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.15785"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,10]]},"references-count":85,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1111\/bjh.15785"],"URL":"https:\/\/doi.org\/10.1111\/bjh.15785","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,10]]},"assertion":[{"value":"2019-02-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}