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The increase in utilization of minimally invasive procedures, such as fine needle aspiration or needle core biopsies, lead to challenges in our ability to make accurate histopathological assessments of disease, including the integration of new diagnostic and prognostic testing, with smaller amounts of material. The trend towards minimally invasive diagnostics is also often in conflicting interest with researchers seeking to study tissue specimens to better understand the biology and genetics of these diseases to move the field forward. Thankfully, there are emerging fields which seek to extract large amounts of diagnostic and prognostic data out of material that is circulating in the blood of patients with lymphoma. Here we will review recent exciting data regarding the use of circulating tumour cells, circulating tumour <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>, and the detection and utility of circulating exosomes and how it can assist in diagnosis, prognosis and therapeutic monitoring. These advances hold the promise to enable continued safe patient care while also advancing discovery, translational and clinical research.<\/jats:p>","DOI":"10.1111\/bjh.15788","type":"journal-article","created":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T04:40:09Z","timestamp":1550637609000},"page":"1136-1141","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Lymphoma diagnostics: getting more from less"],"prefix":"10.1111","volume":"185","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0322-8882","authenticated-orcid":false,"given":"Paul J.","family":"Galardy","sequence":"first","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine Mayo Clinic Rochester MN USA"},{"name":"Department of Biochemistry and Molecular Biology Mayo Clinic Rochester MN USA"},{"name":"Division of Pediatric Haematology\u2010Oncology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tibor","family":"Bedekovics","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Macintyre","sequence":"additional","affiliation":[{"name":"Diagnostic Haematology Necker\u2010Enfants Malades Hospital Assistance Publique H\u00f4pitaux de Paris Universit\u00e9 Paris Descartes Sorbonne Cit\u00e9 Institut Necker\u2010Enfants Malades (INEM) Institut national de recherche m\u00e9dicale (INSERM) U1151 Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodney R.","family":"Miles","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Utah and ARUP Laboratories Salt Lake City UT 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