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The majority, 70\u201380%, is of T\u2010lymphoblastic origin while 20\u201325% arise from B lymphoblasts. With current therapy, the event\u2010free and overall survivals for paediatric\n                    <jats:styled-content style=\"fixed-case\">LBL<\/jats:styled-content>\n                    patients now exceeds 80%. Therapy, especially in T\u2010\n                    <jats:styled-content style=\"fixed-case\">LBL<\/jats:styled-content>\n                    with large mediastinal tumours, is challenging, with both significant morbidity and late sequela. An additional challenge is the dismal prognosis of patients with refractory or relapsed disease. This review article will focus on the growing knowledge of the pathogenesis and biology of\n                    <jats:styled-content style=\"fixed-case\">LBL<\/jats:styled-content>\n                    , recent advances and challenges in the therapy of\n                    <jats:styled-content style=\"fixed-case\">LBL<\/jats:styled-content>\n                    , and ongoing and future efforts and opportunities in optimizing therapy and developing novel targeted treatment approaches.\n                  <\/jats:p>","DOI":"10.1111\/bjh.15793","type":"journal-article","created":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T03:22:55Z","timestamp":1551237775000},"page":"1158-1170","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["Lymphoblastic lymphoma in children and adolescents: review\u00a0of current challenges and future opportunities"],"prefix":"10.1111","volume":"185","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1151-829X","authenticated-orcid":false,"given":"Birgit","family":"Burkhardt","sequence":"first","affiliation":[{"name":"Paediatric Haematology and Oncology University Hospital Muenster Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1790-2679","authenticated-orcid":false,"given":"Michelle L.","family":"Hermiston","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology University of California San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,27]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07320.x"},{"key":"e_1_2_14_3_1","doi-asserted-by":"crossref","first-page":"3610","DOI":"10.1182\/blood.V112.11.3610.3610","article-title":"High\u2010dose methotrexate and early intensification of therapy do not improve 3\u00a0year EFS in children and adolescents with disseminated lymphoblastic lymphoma. 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