{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T16:58:08Z","timestamp":1778086688995,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,2,22]],"date-time":"2019-02-22T00:00:00Z","timestamp":1550793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The use of immunochemotherapy has improved the outcome of follicular lymphoma (<jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>). Recently, complete response at 30\u00a0months (<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>30) has been suggested as a surrogate for progression\u2010free survival. This study aimed to analyse the life expectancy of <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content> patients according to their status at 30\u00a0months from the start of treatment in comparison with the sex and age\u2010matched Spanish general population (relative survival; <jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content>). The training series comprised 263 patients consecutively diagnosed with <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content> in a 10\u2010year period who needed therapy and were treated with rituximab\u2010containing regimens. An independent cohort of 693 <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content> patients from the Grupo Espa\u00f1ol de Linfomas y Trasplante Aut\u00f3logo de M\u00e9dula \u00d3sea (<jats:styled-content style=\"fixed-case\">GELTAMO<\/jats:styled-content>) group was used for validation. In the training cohort, 188 patients were in <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>30, with a 10\u2010year overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) of 53% and 87% for non\u2010<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>30 and <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>30 patients, respectively. Ten\u2010year <jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content> was 73% and 100%, showing no decrease in life expectancy for <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>30 patients. Multivariate analysis indicated that the <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content> International Prognostic Index was the most important variable predicting <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> in the <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>30 group. The impact of <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>30 status on <jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content> was validated in the independent <jats:styled-content style=\"fixed-case\">GELTAMO<\/jats:styled-content> series. In conclusion, <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content> patients treated with immunochemotherapy who were in <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content> at 30\u00a0months showed similar survival to a sex\u2010 and age\u2010matched Spanish general population.<\/jats:p>","DOI":"10.1111\/bjh.15805","type":"journal-article","created":{"date-parts":[[2019,2,22]],"date-time":"2019-02-22T10:40:16Z","timestamp":1550832016000},"page":"480-491","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Life expectancy of follicular lymphoma patients in complete response at 30\u00a0months is similar to that of the Spanish general population"],"prefix":"10.1111","volume":"185","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6928-8386","authenticated-orcid":false,"given":"Laura","family":"Magnano","sequence":"first","affiliation":[{"name":"Haematology Department Hospital Cl\u00ednic 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