{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:45:34Z","timestamp":1747183534851,"version":"3.40.5"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T00:00:00Z","timestamp":1550620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003748","name":"Svenska S\u00e4llskapet f\u00f6r Medicinsk Forskning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Mantle cell lymphoma (<jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content>), a malignancy of B\u2010lymphocytes, has a poor prognosis. It is thus necessary to improve the understanding of the pathobiology of <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content> and identify factors contributing to its aggressiveness. Our studies, based on Affymetrix data from 17 <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content> biopsies, real\u2010time quantitative polymerase chain reaction data from 18 sorted primary <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content> cells and 108 <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content> biopsies compared to non\u2010malignant tissue, reveals that <jats:italic><jats:styled-content style=\"fixed-case\">GNAZ<\/jats:styled-content><\/jats:italic> expression predicts poor clinical outcome of <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content> patients (Cox regression, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7014) and lymphocytosis (Mann\u2010Whitney, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7011). We show that <jats:italic><jats:styled-content style=\"fixed-case\">GNAZ<\/jats:styled-content><\/jats:italic> translates to G\u03b1<jats:sub>z<\/jats:sub> protein \u2013 a signalling molecule within the G\u2010protein coupled receptor network. Our findings suggest that <jats:italic><jats:styled-content style=\"fixed-case\">GNAZ<\/jats:styled-content>\/<\/jats:italic>G\u03b1<jats:sub>z<\/jats:sub> contribute to the <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content> pathobiology.<\/jats:p>","DOI":"10.1111\/bjh.15810","type":"journal-article","created":{"date-parts":[[2019,2,21]],"date-time":"2019-02-21T01:24:01Z","timestamp":1550712241000},"page":"708-712","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Expression of <i><scp>GNAZ<\/scp>,<\/i> encoding the G\u03b1<sub>z<\/sub> protein, predicts survival in mantle cell lymphoma"],"prefix":"10.1111","volume":"185","author":[{"given":"Filip","family":"Mundt","sequence":"first","affiliation":[{"name":"Proteomics and Biomarkers The Broad Institute of MIT and Harvard Boston, Cambridge MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magali","family":"Merrien","sequence":"additional","affiliation":[{"name":"Division of Pathology Department of Laboratory Medicine Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Nygren","sequence":"additional","affiliation":[{"name":"Division of Pathology Department of Laboratory Medicine Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lesley A.","family":"Sutton","sequence":"additional","affiliation":[{"name":"Department of Immunology, Genetics and Pathology Science for Life Laboratory Uppsala University Uppsala Sweden"},{"name":"Department of Molecular Medicine and Surgery Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birger","family":"Christensson","sequence":"additional","affiliation":[{"name":"Division of Pathology Department of 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Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5020-3856","authenticated-orcid":false,"given":"Agata M.","family":"Wasik","sequence":"additional","affiliation":[{"name":"Division of Pathology Department of Laboratory Medicine Karolinska Institutet Stockholm 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