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In its classical form, significant combined immune deficiency, autoimmune complications and risk of haematological malignancy necessitate early correction with stem cell transplantation or gene therapy. A\u00a0milder form, X\u2010linked thrombocytopaenia (XLT), shares similar bleeding risk from thrombocytopaenia but is not associated with other significant clinical features and is generally managed conservatively. Here, we detail our approach to the diagnosis and treatment of classical WAS and XLT.<\/jats:p>","DOI":"10.1111\/bjh.15831","type":"journal-article","created":{"date-parts":[[2019,3,13]],"date-time":"2019-03-13T01:59:10Z","timestamp":1552442350000},"page":"647-655","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["How I manage patients with Wiskott Aldrich syndrome"],"prefix":"10.1111","volume":"185","author":[{"given":"Elizabeth","family":"Rivers","sequence":"first","affiliation":[{"name":"University College London Great Ormond Street Institute of Child Health London UK"},{"name":"Great Ormond Street Hospital for Children NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Austen","family":"Worth","sequence":"additional","affiliation":[{"name":"Great Ormond Street Hospital for Children NHS Foundation Trust London 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