{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T12:48:34Z","timestamp":1786366114406,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T00:00:00Z","timestamp":1552348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2019,6]]},"abstract":"Summary<\/jats:title>The role of Ann Arbor staging in determining treatment intensity after achieving a negative positron emission tomography (PET<\/jats:styled-content>) has not been established in classical Hodgkin lymphoma (cHL<\/jats:styled-content>). Patients with stage I\u2013IV cHL<\/jats:styled-content>, received three cycles of ABVD<\/jats:styled-content> (doxorubicin, bleomycin, vinblastine, dacarbazine) and an interim PET<\/jats:styled-content> scan (PET<\/jats:styled-content>3). PET<\/jats:styled-content>3\u2010negative patients received no further therapy. PET<\/jats:styled-content>3\u2010positive patients received three additional cycles of ABVD<\/jats:styled-content> plus involved\u2010field radiation therapy or salvage chemotherapy, if refractory to ABVD<\/jats:styled-content>, and were re\u2010evaluated by PET<\/jats:styled-content> scan (PET<\/jats:styled-content>6). Study endpoints were 3\u2010year progression\u2010free survival (PFS<\/jats:styled-content>) and overall survival (OS<\/jats:styled-content>) rates. Two hundred and thirty\u2010nine patients with early\u2010stage and 138 with advanced\u2010stage were evaluable. Overall, 260 patients (70%) were PET<\/jats:styled-content>3\u2010negative and had higher 3\u2010year PFS<\/jats:styled-content> (90% vs. 65%; P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0\u00b70001) and OS<\/jats:styled-content> (98% vs. 92%; P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0\u00b7007) rates than PET<\/jats:styled-content>3\u2010positive patients. All PET<\/jats:styled-content>3\u2010negative patients, regardless of disease stage at diagnosis, achieved similarly good PFS<\/jats:styled-content> (90\u201391%; P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0\u00b776) and OS<\/jats:styled-content> (97\u201399%). The only independent prognostic factor for PFS<\/jats:styled-content> was PET<\/jats:styled-content>3\u2010negativity (Hazard ratio 3\u00b78; 95% confidence interval 2\u00b74\u20136\u00b73; P<\/jats:italic>\u00a0<\u00a00\u00b70001). This study suggests that cHL<\/jats:styled-content> patients who achieve a negative PET<\/jats:styled-content>3 following ABVD<\/jats:styled-content> have an excellent outcome, regardless of stage at diagnosis. An appropriately powered, phase III<\/jats:styled-content> trial will be necessary to confirm these findings.<\/jats:p>","DOI":"10.1111\/bjh.15838","type":"journal-article","created":{"date-parts":[[2019,3,13]],"date-time":"2019-03-13T02:19:44Z","timestamp":1552443584000},"page":"865-873","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["PET<\/scp>\u2010adapted therapy after three cycles of ABVD<\/scp> for all stages of Hodgkin lymphoma: results of the GATLA LH<\/scp>\u201005 trial"],"prefix":"10.1111","volume":"185","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2068-3721","authenticated-orcid":false,"given":"Astrid","family":"Pavlovsky","sequence":"first","affiliation":[{"name":"Haematology Fundaleu Buenos Aires Argentina"},{"name":"Haematology Centro de Hematologia Pavlovsky Buenos Aires 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