{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:01:29Z","timestamp":1790254889555,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T00:00:00Z","timestamp":1552348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Immunological mechanisms of treatment\u2010free remission (TFR) in chronic myeloid leukaemia (CML) are poorly defined and, to date, no correlation between successful TFR and CD8(+) T\u2010cell subsets has been found. We analysed a new identified human subset of CD8(+) T\u2010cells, namely innate CD8(+) T\u2010cells, in CML patients with TFR\u00a0\u2265\u00a02\u00a0years. We demonstrated a dramatic increase of functionally active innate CD8(+) T\u2010cells in these patients as compared to control subjects and patients in remission under tyrosine kinase inhibitors. Moreover, we found a positive correlation between frequencies of innate CD8(+) T\u2010cells and natural killer cells, possibly representing a new innate biomarker profile of successful TFR.<\/jats:p>","DOI":"10.1111\/bjh.15858","type":"journal-article","created":{"date-parts":[[2019,3,13]],"date-time":"2019-03-13T02:15:48Z","timestamp":1552443348000},"page":"54-59","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Sustained treatment\u2010free remission in chronic myeloid leukaemia is associated with an increased frequency of innate CD8(+) T\u2010cells"],"prefix":"10.1111","volume":"186","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1654-5948","authenticated-orcid":false,"given":"Emilie","family":"Cayssials","sequence":"first","affiliation":[{"name":"INSERM 1082 Poitiers France"},{"name":"Service d'Oncologie H\u00e9matologique de Th\u00e9rapie Cellulaire CHU de Poitiers Poitiers 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