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Inhibitors of phosphoinositide 3\u2010kinase delta (<jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>3K\u03b4) cause release of <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content> cells from lymphoid tissues into blood. <jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>3K\u03b4 inhibitors are thought to target only <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content> and other immune cells because <jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>3K\u03b4 expression is restricted to haematopoietic cells. We found that <jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>3K\u03b4 is unexpectedly expressed in primary <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content> derived from <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content> patients and healthy donors. <jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>3K\u03b4 inhibition in <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content> using idelalisib or duvelisib significantly reduced their ability to support <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content> migration and adhesion. These observations provide the first evidence that <jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>3K\u03b4 is expressed and functional in <jats:styled-content style=\"fixed-case\">CLL MSC<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/bjh.15865","type":"journal-article","created":{"date-parts":[[2019,3,15]],"date-time":"2019-03-15T02:14:26Z","timestamp":1552616066000},"page":"883-887","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Expression and function of phosphoinositide 3\u2010kinase delta in mesenchymal stromal cells from normal and leukaemic bone marrow"],"prefix":"10.1111","volume":"185","author":[{"given":"Ahmed Y.","family":"Ali","sequence":"first","affiliation":[{"name":"Department of Immunology University of Manitoba Winnipeg Canada"},{"name":"Research Institute in Oncology and Hematology CancerCare Manitoba Winnipeg 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