{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:10:49Z","timestamp":1787314249620,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T00:00:00Z","timestamp":1553644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI14\/01971 FI"],"award-info":[{"award-number":["PI14\/01971 FI"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["2017\u2010SGR288"],"award-info":[{"award-number":["2017\u2010SGR288"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010434","name":"\u201cLa Caixa\u201d Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010434","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["CERCA Program"],"award-info":[{"award-number":["CERCA Program"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010147","name":"Asociaci\u00f3n Espa\u00f1ola de Pediatr\u00eda","doi-asserted-by":"publisher","award":["AECC (GC16173697BIGA)"],"award-info":[{"award-number":["AECC (GC16173697BIGA)"]}],"id":[{"id":"10.13039\/100010147","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    The prognostic significance of low\u2010hypodiploidy has not been extensively evaluated in minimal residual disease (MRD)\u2010oriented protocols for adult acute lymphoblastic leukaemia (ALL). We analysed the outcome of hypodiploid adult ALL patients treated within Programa Espa\u00f1ol de Tratamientos en Hematolog\u00eda (PETHEMA) protocols. The 5\u2010year cumulative incidence of relapse (CIR) of low\u2010hypodiploid B\u2010cell precursor (BCP)\u2010ALL was significantly higher than that of high\u2010hypodiploids (52% vs. 12%,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.013). Low\u2010hypodiploid BCP\u2010ALL patients aged \u226435\u00a0years showed superior survival (71% vs. 21%,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.026) and lower 5\u2010year CIR (17% vs. 66%,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.090) than low\u2010hypodiploids aged &gt;35\u00a0years. Older adults and elderly low\u2010hypodiploid BCP\u2010ALL patients show dismal prognosis although achieving an end\u2010induction good MRD response.\n                  <\/jats:p>","DOI":"10.1111\/bjh.15887","type":"journal-article","created":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T17:16:50Z","timestamp":1553707010000},"page":"263-268","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The poor prognosis of low hypodiploidy in adults with B\u2010cell precursor acute lymphoblastic leukaemia is restricted to older adults and elderly patients"],"prefix":"10.1111","volume":"186","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4796-6470","authenticated-orcid":false,"given":"Jordi","family":"Ribera","sequence":"first","affiliation":[{"name":"Institut de Recerca contra la Leucemia Josep Carreras Hospital Germans Trias i Pujol Universitat Aut\u00f2noma de Barcelona Badalona 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Barcelona Badalona Spain"},{"name":"Institut Catal\u00e0 d'Oncologia Hospital Germans Trias i Pujol Badalona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eul\u00e0lia","family":"Genesc\u00e0","sequence":"additional","affiliation":[{"name":"Institut de Recerca contra la Leucemia Josep Carreras Hospital Germans Trias i Pujol Universitat Aut\u00f2noma de Barcelona Badalona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Institut de Recerca contra la Leucemia Josep Carreras Hospital Germans Trias i Pujol Universitat Aut\u00f2noma de Barcelona Badalona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Nomdedeu","sequence":"additional","affiliation":[{"name":"Institut de Recerca contra la Leucemia Josep Carreras Hospital Sant Pau Barcelona 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treatment with chemotherapy or allogeneic hematopoietic stem cell transplantation (alloHSCT) of high\u2010risk (HR) philadelphia chromosome\u2010negative (Ph\u2010neg) adult acute lymphoblastic leukemia (ALL) according to minimal residual disease (MRD). Preliminary results of the Pethema ALL\u2010HR\u201011 trial","volume":"126","author":"Ribera J.M.","year":"2015","journal-title":"Blood"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2016.263"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjh.15887","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.15887","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.15887","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.15887","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T17:00:32Z","timestamp":1694365232000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.15887"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,27]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1111\/bjh.15887"],"URL":"https:\/\/doi.org\/10.1111\/bjh.15887","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,27]]},"assertion":[{"value":"2019-01-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}