{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T14:24:41Z","timestamp":1771338281705,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T00:00:00Z","timestamp":1554163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001219","name":"Lymphoma Research Foundation","doi-asserted-by":"publisher","award":["337589"],"award-info":[{"award-number":["337589"]}],"id":[{"id":"10.13039\/100001219","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Cancer cachexia is a state of involuntary weight loss and altered body composition triggered by an underlying malignancy. We sought to correlate measures of cachexia with clinical outcomes in aggressive lymphomas and to identify biological pathways involved in the cachexia phenotype for possible druggable targets. Radiographic measures of cachexia were collected in a retrospective cohort of 109 patients with aggressive B\u2010cell lymphoma and followed for clinical outcome. We found males with sarcopenia had reduced progression\u2010free survival (5\u00b74 vs. 72\u00b73\u00a0months, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b70005) and overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>; 30\u00b72\u00a0months vs. not reached, <jats:styled-content style=\"fixed-case\">NR<\/jats:styled-content>,<jats:italic> P<\/jats:italic>\u00a0=\u00a00\u00b702); males with adipopenia also had decreased <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> (21\u00b76\u00a0months vs. <jats:styled-content style=\"fixed-case\">NR<\/jats:styled-content>,<jats:italic> P<\/jats:italic>\u00a0=\u00a00\u00b704). A trend for increased <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> was observed in female sarcopenics only (32\u00b78\u00a0months vs. <jats:styled-content style=\"fixed-case\">NR<\/jats:styled-content>,<jats:italic> P<\/jats:italic>\u00a0=\u00a00\u00b708). Additionally, we analysed a prospective cohort of 14 patients for differences in circulating molecular targets involved in various biological pathways. There was a significant correlation with cachexia for reduced serum levels of mediators within the glucose utilization [insulin \u2010like growth factor (<jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content>)\u2010binding protein 6, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b704; <jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content>\u20101, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b702], inflammation (lymphotoxin\u2010like inducible protein that competes with glycoprotein D for herpesvirus entry on T cells; <jats:styled-content style=\"fixed-case\">LIGHT<\/jats:styled-content>,<jats:italic> P<\/jats:italic>\u00a0=\u00a00\u00b7005), and energy intake\/expenditure (leptin, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7004). We conclude that cachexia in patients with aggressive lymphomas has sex\u2010specific prognostic utility and correlates with measurable changes in metabolism and immune function.<\/jats:p>","DOI":"10.1111\/bjh.15889","type":"journal-article","created":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T03:33:56Z","timestamp":1554262436000},"page":"45-53","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Evaluation of the impact of cachexia on clinical outcomes in aggressive lymphoma"],"prefix":"10.1111","volume":"186","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5105-0564","authenticated-orcid":false,"given":"Madelyn","family":"Burkart","sequence":"first","affiliation":[{"name":"Northwestern University Feinberg School of Medicine Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Schieber","sequence":"additional","affiliation":[{"name":"Robert H. Lurie Comprehensive Cancer Center Northwestern University Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjib","family":"Basu","sequence":"additional","affiliation":[{"name":"Rush University Medical Center Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Palmi","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Radiology Rush University Medical Center Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parameswaran","family":"Venugopal","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology and Cell Therapy Rush University Medical Center Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey A.","family":"Borgia","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Biochemistry Rush University Medical Center Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leo","family":"Gordon","sequence":"additional","affiliation":[{"name":"Robert H. Lurie Comprehensive Cancer Center Northwestern University Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reem","family":"Karmali","sequence":"additional","affiliation":[{"name":"Rush University Medical Center Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu101"},{"key":"e_1_2_5_3_1","unstructured":"American Cancer Society. (2018)Cancer Facts & Figures 2018. 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