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We performed a prospective study evaluating plasma histamine and tryptase levels in a cohort of paediatric and adult patients, in steady state (<jats:italic>n<\/jats:italic>\u00a0=\u00a0132) and during vaso\u2010occlusive crisis (<jats:styled-content style=\"fixed-case\">VOC<\/jats:styled-content>) (<jats:italic>n<\/jats:italic>\u00a0=\u00a0121). Histamine level was elevated in 18% of patients in steady state and in 61% during <jats:styled-content style=\"fixed-case\">VOC<\/jats:styled-content>. Median histamine level was significantly higher during <jats:styled-content style=\"fixed-case\">VOC<\/jats:styled-content> than in steady state (24\u00b71 [7\u00b70\u201345\u00b70] vs 9\u00b76 [6\u00b72\u201314\u00b74]\u00a0nmol\/l, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b70001). Tryptase level was slightly increased during <jats:styled-content style=\"fixed-case\">VOC<\/jats:styled-content> without reaching pathological values. These results suggest a role of mast cell activation in <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> pathophysiology.<\/jats:p>","DOI":"10.1111\/bjh.15900","type":"journal-article","created":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T02:55:32Z","timestamp":1553828132000},"page":"125-129","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Plasma histamine elevation in a large cohort of sickle cell disease patients"],"prefix":"10.1111","volume":"186","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7068-4530","authenticated-orcid":false,"given":"Slimane","family":"Allali","sequence":"first","affiliation":[{"name":"Department of General Paediatrics and Paediatric Infectious Diseases Necker Hospital for Sick Children Assistance Publique \u2013 H\u00f4pitaux de Paris (AP\u2010HP) Paris Descartes University Paris France"},{"name":"Laboratory of Cellular and Molecular Mechanisms of Haematological Disorders and Therapeutical Implications Paris Descartes \u2013 Sorbonne Paris Cite \u0301 University Imagine Institute Inserm U1163 Paris France"},{"name":"Laboratory of Excellence GR\u2010Ex Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Lionnet","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Tenon Hospital AP\u2010HP Paris VI University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Mattioni","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Tenon Hospital AP\u2010HP Paris VI University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Callebert","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Inserm UMR942 Lariboisi\u00e8re Hospital AP\u2010HP Paris Descartes University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Stankovic Stojanovic","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Tenon Hospital AP\u2010HP Paris VI University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Bachmeyer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Tenon Hospital AP\u2010HP Paris VI University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Benoit","family":"Arlet","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular and Molecular Mechanisms of Haematological Disorders and Therapeutical Implications Paris Descartes \u2013 Sorbonne Paris Cite \u0301 University Imagine Institute Inserm U1163 Paris France"},{"name":"Laboratory of Excellence GR\u2010Ex Paris France"},{"name":"Department of Internal Medicine Georges\u2010Pompidou European Hospital AP\u2010HP Paris Descartes University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentine","family":"Brousse","sequence":"additional","affiliation":[{"name":"Department of General Paediatrics and Paediatric Infectious Diseases Necker Hospital for Sick Children Assistance Publique \u2013 H\u00f4pitaux de Paris (AP\u2010HP) Paris Descartes University Paris France"},{"name":"Laboratory of Excellence GR\u2010Ex Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariane","family":"de Montalembert","sequence":"additional","affiliation":[{"name":"Department of General Paediatrics and Paediatric Infectious Diseases Necker Hospital for Sick Children Assistance Publique \u2013 H\u00f4pitaux de Paris (AP\u2010HP) Paris Descartes University Paris France"},{"name":"Laboratory of Excellence GR\u2010Ex Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Chalumeau","sequence":"additional","affiliation":[{"name":"Department of General Paediatrics and Paediatric Infectious Diseases Necker Hospital for Sick Children Assistance Publique \u2013 H\u00f4pitaux de Paris (AP\u2010HP) Paris Descartes University Paris France"},{"name":"Laboratory of Excellence GR\u2010Ex Paris France"},{"name":"Obstetrical, Perinatal and Paediatric Epidemiology Research Team (EPOP\u00e9) Inserm UMR1153 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Grateau","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Tenon Hospital AP\u2010HP Paris VI University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago T.","family":"Maciel","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular and Molecular Mechanisms of Haematological Disorders and Therapeutical 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