{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T18:30:00Z","timestamp":1794249000534,"version":"4.9.0"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T00:00:00Z","timestamp":1554940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>There is insufficient evidence linking excess body weight to risk of myeloid malignancies. We investigated this association using data from the Cancer Prevention Study\u2010<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>(<jats:styled-content style=\"fixed-case\">CPS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>), and a meta\u2010analysis of published cohort studies. Among 152\u00a0090<jats:styled-content style=\"fixed-case\">CPS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>participants, 387 acute myeloid leukaemias (<jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>), 100 chronic myeloid leukaemias (<jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content>) and 170<jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content>were identified over 21\u00a0years of follow\u2010up. In<jats:styled-content style=\"fixed-case\">CPS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>, body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>) was weakly associated with risk of<jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content>(hazard ratio [<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>]\u00a0=\u00a01\u00b704, 95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>]: 0\u00b799\u20131\u00b709 per 1\u00a0unit increase in<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>),<jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>(<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u00a0=\u00a01\u00b701, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0\u00b798\u20131\u00b703) and<jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content>(<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u00a0=\u00a01\u00b703, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0\u00b799\u20131\u00b707). After controlling for other anthropometric factors, no clear association was observed for height,<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>at age 18\u00a0years or weight change. In the meta\u2010analysis (<jats:italic>n<\/jats:italic>\u00a0=\u00a07117 myeloid leukaemias),<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>25\u201329\u00b79\u00a0kg\/m<jats:sup>2<\/jats:sup>(<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content><jats:sub>pooled<\/jats:sub>\u00a0=\u00a01\u00b736, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1\u00b712\u20131\u00b759) and<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\u226530\u00a0kg\/m<jats:sup>2<\/jats:sup>(<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content><jats:sub>pooled<\/jats:sub>\u00a0=\u00a01\u00b743, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1\u00b718\u20131\u00b769) were associated with higher risk of myeloid leukaemia overall, compared to a<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>&lt;25\u00a0kg\/m<jats:sup>2<\/jats:sup>. Likewise,<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\u226525\u00a0kg\/m<jats:sup>2<\/jats:sup>was positively associated with both<jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content>risk individually in the meta\u2010analysis. These results underscore the need for large studies to detect associations with rare cancers, and show a modest, but positive association between excess body weight and myeloid malignancy risk.<\/jats:p>","DOI":"10.1111\/bjh.15904","type":"journal-article","created":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T09:07:50Z","timestamp":1555060070000},"page":"243-254","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Anthropometric factors and risk of myeloid leukaemias and myelodysplastic syndromes: a prospective study and meta\u2010analysis"],"prefix":"10.1111","volume":"186","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2419-8536","authenticated-orcid":false,"given":"Lauren R.","family":"Teras","sequence":"first","affiliation":[{"name":"Epidemiology Research Program American Cancer Society Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alpa 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