{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T01:15:23Z","timestamp":1780362923217,"version":"3.54.1"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T00:00:00Z","timestamp":1558483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","award":["RP\u20102\u201016\u201007\u2010001"],"award-info":[{"award-number":["RP\u20102\u201016\u201007\u2010001"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003921","name":"Department of Health, Australian Government","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:sup>18<\/jats:sup>F\u2010fluoro\u20102\u2010deoxy\u2010D\u2010glucose positron emission tomography\/computed tomography (<jats:styled-content style=\"fixed-case\">FDG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>) is used for staging classical Hodgkin lymphoma (<jats:styled-content style=\"fixed-case\">cHL<\/jats:styled-content>) with high sensitivity for skeletal involvement. However, it is unclear whether a single bone lesion carries the same adverse prognosis as multifocal lesions and if this is affected by type of chemotherapy [<jats:styled-content style=\"fixed-case\">ABVD<\/jats:styled-content> (adriamycin, bleomycin, vincristine, dacarbazine) <jats:italic>versus <\/jats:italic><jats:styled-content style=\"fixed-case\">BEACOPP<\/jats:styled-content> (bleomycin, etoposide, adriamycin, cyclophosphamide, vincristine, procarbazine, prednisone)]. We reviewed the clinico\u2010pathological and outcome data from 209 patients with newly diagnosed <jats:styled-content style=\"fixed-case\">cHL<\/jats:styled-content> staged by <jats:styled-content style=\"fixed-case\">FDG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>. Patterns of skeletal\/bone marrow uptake (<jats:styled-content style=\"fixed-case\">BMU<\/jats:styled-content>) were divided into \u2018low\u2019 and \u2018high\u2019 diffuse <jats:styled-content style=\"fixed-case\">BMU<\/jats:styled-content> (i.e. without focal lesions), and unifocal or multifocal lesions. Additional separate survival analysis was performed, taking type of chemotherapy into account. Forty patients (19\u00b72%) had skeletal lesions (20 unifocal, 20 multifocal). The 3\u2010year progression\u2010free\u2010survival (<jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content>) was 80% for patients with \u2018low <jats:styled-content style=\"fixed-case\">BMU<\/jats:styled-content>\u2019, 87% for \u2018high <jats:styled-content style=\"fixed-case\">BMU<\/jats:styled-content>\u2019, 69% for \u2018unifocal\u2019 and 51% for \u2018multifocal\u2019 lesions; median follow\u2010up was 38\u00a0months. The presence of bone lesions, both uni\u2010 and multifocal, was associated with significantly inferior <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content> (log rank <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b70001), independent of chemotherapy type. Thus, increased diffuse <jats:styled-content style=\"fixed-case\">BMU<\/jats:styled-content> should not be considered as a risk factor in <jats:styled-content style=\"fixed-case\">cHL<\/jats:styled-content>, whereas unifocal or multifocal bone lesions should be regarded as important predictors of adverse outcome, irrespective of the chemotherapy regimen used.<\/jats:p>","DOI":"10.1111\/bjh.15933","type":"journal-article","created":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T09:26:43Z","timestamp":1558517203000},"page":"431-439","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Focal skeletal <scp>FDG<\/scp> uptake indicates poor prognosis in <scp>cHL<\/scp> regardless of extent and first\u2010line chemotherapy"],"prefix":"10.1111","volume":"186","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8670-939X","authenticated-orcid":false,"given":"Mette A.","family":"Pedersen","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine &amp; PET\u2010Centre Aarhus University Hospital Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0144-1305","authenticated-orcid":false,"given":"Lars C.","family":"Gormsen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine &amp; PET\u2010Centre Aarhus University Hospital Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kamper","sequence":"additional","affiliation":[{"name":"Department of Haematology Aarhus University Hospital Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Wassberg","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Uppsala University Hospital Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja D.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Haematology Aarhus University Hospital Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander L.","family":"d'Amore","sequence":"additional","affiliation":[{"name":"Department of Haematology Aarhus University Hospital Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2516-5288","authenticated-orcid":false,"given":"Sally F.","family":"Barrington","sequence":"additional","affiliation":[{"name":"King's College London and Guy's and St Thomas\u2019 PET Centre School of Biomedical Engineering and Imaging Sciences King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Johnson","sequence":"additional","affiliation":[{"name":"Cancer Research UK Centre University of Southampton Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2158-3885","authenticated-orcid":false,"given":"Stephen","family":"Hamilton\u2010Dutoit","sequence":"additional","affiliation":[{"name":"Department of Pathology Aarhus University Hospital Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0901-5252","authenticated-orcid":false,"given":"Rose\u2010Marie","family":"Amini","sequence":"additional","affiliation":[{"name":"Department of Pathology Uppsala University Hospital Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunilla","family":"Enblad","sequence":"additional","affiliation":[{"name":"Department of Oncology Uppsala University Hospital Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Molin","sequence":"additional","affiliation":[{"name":"Department of Oncology Uppsala University Hospital Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"d'Amore","sequence":"additional","affiliation":[{"name":"Department of Haematology Aarhus University Hospital Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12483"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-012-0665-5"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-11-679407"},{"key":"e_1_2_8_5_1","first-page":"1860","article-title":"Report of the Committee on Hodgkin's Disease Staging Classification","volume":"31","author":"Carbone P.P.","year":"1971","journal-title":"Cancer Research"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24044"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.42.4036"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61940-5"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.43.4803"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199811193392104"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-014-2783-x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-12-473389"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-013-2443-6"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2011.593273"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1995.13.2.403"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-009-1183-0"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-014-2822-7"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2016.1193856"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12282"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2013-201520"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1989.tb00268.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/13.S1.67"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjh.15933","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.15933","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.15933","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.15933","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T10:54:22Z","timestamp":1692874462000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.15933"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,22]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1111\/bjh.15933"],"URL":"https:\/\/doi.org\/10.1111\/bjh.15933","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,22]]},"assertion":[{"value":"2018-12-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}