{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:47:24Z","timestamp":1790740044010,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T00:00:00Z","timestamp":1558656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Given the lack of consistent data regarding the clinico\u2010pathological features and clonal lymphomagenesis of patients with mucosa\u2010associated lymphoid tissue (<jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content>) lymphoma and histological transformation (<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>), we have systematically analysed 379 patients (32% gastric, 68% extra\u2010gastric; median follow\u2010up 52\u00a0months) diagnosed with <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> at the Medical University Vienna 1999\u20132017, and reassessed tissues of identified patients by polymerase chain reaction (<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>)\u2010based clonality analysis. <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> was documented in 12\/379 patients (3\u00b72%) and occurred at a median time of 22\u00a0months (range; 6\u2013202\u00a0months) after diagnosis of <jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content> lymphoma. By <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\u2010based clonality analysis, we detected a clear\u2010cut clonal relationship of <jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content> lymphoma and diffuse large B\u2010cell lymphoma (<jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content>) in 8 of 11 analysed cases proving that the large majority of <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> following <jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content> lymphoma are clonally\u2010related and constitute a real transformation. Interestingly, <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> occurred within the first 2\u00b75\u00a0years after diagnosis in patients with clonal relationship, whereas time to aggressive lymphoma was longer in patients identified as clonally\u2010unrelated (most likely secondary) lymphoma (82\u2013202\u00a0months), suggesting that <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> is an early event in this disease. Survival of patients with <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> was poor with 6\/12 dying at 1\u00b75\u201333\u00a0months after <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>, however, patients with localized gastric transformation had a superior outcome with only 1\/6 dying due to progression of lymphoma.<\/jats:p>","DOI":"10.1111\/bjh.15953","type":"journal-article","created":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T09:01:56Z","timestamp":1558688516000},"page":"448-459","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Transformed mucosa\u2010associated lymphoid tissue lymphomas: A single institution retrospective study including polymerase chain reaction\u2010based clonality 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