{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T02:47:19Z","timestamp":1789958839036,"version":"4.0.1"},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T00:00:00Z","timestamp":1557878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Standard first\u2010line therapy choice for essential thrombocythaemia (<jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>) requiring cytoreduction, supported by randomized trials, is low\u2010dose aspirin with hydroxycarbamide, but the role of recombinant interferon\u2010alfa (<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u03b1)\u20102a\/2b and pegylated (<jats:styled-content style=\"fixed-case\">PEG<\/jats:styled-content>)\u2010<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b1\u20102a\/2b is increasingly highlighted. Longer\u2010term outcome data, however, remains somewhat scarce, particularly in the \u2018real world'. We hereby report on a large, well\u2010annotated cohort of <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content> patients from a single referral centre undergoing therapy with either <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u03b1 or (<jats:styled-content style=\"fixed-case\">PEG<\/jats:styled-content>)\u2010<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b1\u20102a\/2b and demonstrate high rates of complete haematological responses, good tolerability and safety, low rates of thromboembolic events in compliant patients and confirm feasibility of long\u2010term therapy in a significant proportion of patients.<\/jats:p>","DOI":"10.1111\/bjh.15968","type":"journal-article","created":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T14:11:24Z","timestamp":1557929484000},"page":"561-564","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Essential thrombocythaemia treated with recombinant interferon: \u2018real world' United Kingdom referral centre experience"],"prefix":"10.1111","volume":"186","author":[{"given":"Joana","family":"Desterro","sequence":"first","affiliation":[{"name":"Department of Haematology Guy's and St. Thomas' NHS Foundation Trust London UK"},{"name":"Servi\u00e7o de Hematologia Instituto Portugu\u00eas de Oncologia de Lisboa Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1224-091X","authenticated-orcid":false,"given":"Donal P.","family":"McLornan","sequence":"additional","affiliation":[{"name":"Department of Haematology Guy's and St. Thomas' NHS Foundation Trust London UK"},{"name":"Comprehensive Cancer Centre King's College London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1437-4583","authenticated-orcid":false,"given":"Natalia","family":"Curto Garcia","sequence":"additional","affiliation":[{"name":"Department of Haematology Guy's and St. Thomas' NHS Foundation Trust London UK"},{"name":"Comprehensive Cancer Centre King's College London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0502-7133","authenticated-orcid":false,"given":"Jennifer","family":"O'Sullivan","sequence":"additional","affiliation":[{"name":"Department of Haematology Guy's and St. Thomas' NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samah","family":"Alimam","sequence":"additional","affiliation":[{"name":"Department of Haematology Guy's and St. Thomas' NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clodagh","family":"Keohane","sequence":"additional","affiliation":[{"name":"Department of Haematology Guy's and St. Thomas' NHS Foundation Trust London 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