{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T05:55:27Z","timestamp":1789883727583,"version":"4.0.1"},"reference-count":49,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T00:00:00Z","timestamp":1558656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004416","name":"Vlaamse Liga Tegen Kanker","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Outcomes in childhood T\u2010cell acute lymphoblastic leukaemia (T\u2010ALL) are steadily improving due to intensive therapy. Between 1989 and 2008, 599 children with newly diagnosed T\u2010ALL were enrolled in two successive European Organization for Research and Treatment of Cancer\u00a0\u2010\u00a0Children's Leukaemia Group trials (58881 and 58951), both based on\u00a0the Berlin\u2010Frankfurt\u2010Munster protocol and without cranial irradiation. In the latter\u00a0trial induction chemotherapy was intensified. The most important randomizations were Medac\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    asparaginase\n                    <jats:italic>versus Erwinia<\/jats:italic>\n                    asparaginase in trial 58881, and dexamethasone (6\u00a0mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    \/day)\n                    <jats:italic>versus<\/jats:italic>\n                    prednisolone (60\u00a0mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    \/day) and prolonged\n                    <jats:italic>versus<\/jats:italic>\n                    conventional asparaginase duration in trial 58951. 8\u2010year event\u2010free survival (EFS) increased from 65\u00b71% to 74\u00b70% in trial 58951. Improvement was most profound for patients with white blood cell (WBC) counts &lt;100\u00a0\u00d7\u00a010\n                    <jats:sup>9<\/jats:sup>\n                    \/l and \u201cgood responders\u201d to prephase. Medac\n                    <jats:italic>E.\u00a0coli<\/jats:italic>\n                    asparaginase was associated with longer EFS [hazard ratio (HR) 0\u00b754,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00\u00b70015] and overall survival (HR 0\u00b751,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00\u00b70018). Induction therapy with dexamethasone did not improve EFS compared to prednisolone. Remarkably, intensification of central nervous system (CNS)\u2010directed therapy in trial 58951 resulted in fewer bone marrow relapses, while the incidence of CNS relapses remained low. In summary, we showed that adequate asparaginase therapy, intensified induction treatment and intensification of CNS\u2010directed chemotherapy can result in an improvement of outcome in T\u2010ALL patients with good prephase response and initial WBC counts &lt;100\u00a0\u00d7\u00a010\n                    <jats:sup>9<\/jats:sup>\n                    \/l, representing approximately 50% of T\u2010ALL patients.\n                  <\/jats:p>","DOI":"10.1111\/bjh.15983","type":"journal-article","created":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T06:34:18Z","timestamp":1558679658000},"page":"741-753","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Results of successive EORTC\u2010CLG 58\u00a0881 and 58\u00a0951 trials in paediatric T\u2010cell acute lymphoblastic leukaemia (ALL)"],"prefix":"10.1111","volume":"186","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2061-7617","authenticated-orcid":false,"given":"Mattias","family":"Hofmans","sequence":"first","affiliation":[{"name":"Paediatric Haematology\u2010Oncology and Stem Cell Transplantation Ghent University Hospital Ghent Belgium"},{"name":"Department of Diagnostic Sciences Ghent University Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Suciu","sequence":"additional","affiliation":[{"name":"EORTC Headquarters Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Ferster","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haematology\u2010Oncology Children's University Hospital Queen Fabiola Universit\u00e9 Libre de Bruxelles Brussels 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