{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T03:27:46Z","timestamp":1785554866114,"version":"3.56.0"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T00:00:00Z","timestamp":1559088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Unlike <jats:styled-content style=\"fixed-case\">AL<\/jats:styled-content> amyloid and cast nephropathy, the long\u2010term outcomes of monoclonal gammopathy of renal significance (<jats:styled-content style=\"fixed-case\">MGRS<\/jats:styled-content>) patients with other renal histopathologies remain unclear. It is uncertain if early intervention improves renal outcomes, because of a lack of evidence from prospective studies. In this retrospective study, we examined outcomes of 41 <jats:styled-content style=\"fixed-case\">MGRS<\/jats:styled-content> patients treated between 2004 and 2017 across five centres: four in the <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content> and one in the Republic of Ireland. The primary outcome measure was renal survival estimated by Kaplan\u2013Meier product\u2010limit method. Thirty\u2010three patients (80\u00b75%) were kappa light chain (<jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>) restricted. Twenty\u2010seven patients (65\u00b79%) presented with <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content> deposition disease on renal histology. At 24\u00a0months follow\u2010up, estimated renal survival was 81\u00b76% for the whole cohort. The estimated overall survival was 80\u00b73% at 48\u00a0months. At 24\u00a0months, patients who had chronic kidney disease (<jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>) stage 2\u20133b at diagnosis showed an estimated renal survival of 100% compared to 80\u00b77% in those with <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> stage 4\u20135 at diagnosis (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b704). Poorer outcomes in <jats:styled-content style=\"fixed-case\">MGRS<\/jats:styled-content> patients were historically attributed to delayed diagnosis due to small plasma cell clones, as well as the need for renal biopsy.<\/jats:p>","DOI":"10.1111\/bjh.15987","type":"journal-article","created":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T14:02:19Z","timestamp":1559138539000},"page":"706-716","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Long term outcomes in monoclonal gammopathy of renal significance"],"prefix":"10.1111","volume":"186","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5674-5015","authenticated-orcid":false,"given":"Akhil","family":"Khera","sequence":"first","affiliation":[{"name":"Department of Haematology Oxford University Hospitals NHS Foundation Trust 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