{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:29:15Z","timestamp":1790666955826,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T00:00:00Z","timestamp":1559001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50 CA97274"],"award-info":[{"award-number":["P50 CA97274"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 CA195568"],"award-info":[{"award-number":["U01 CA195568"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The diabetes mellitus (DM) drug metformin targets mechanistic\/mammalian target of rapamycin and inhibits lymphoma growth <jats:italic>in vitro<\/jats:italic>. We investigated whether metformin affected outcomes of newly diagnosed diffuse large B\u2010cell (DLBCL, <jats:italic>n<\/jats:italic>\u00a0=\u00a0869) and follicular lymphoma (FL, <jats:italic>n<\/jats:italic>\u00a0=\u00a0895) patients enrolled in the Mayo component of the Molecular Epidemiology Resource cohort study between 2002 and 2015. Hazard ratios (HR) and 95% confidence intervals (CIs) adjusted for age, sex, body mass index, prognostic index and treatment were used to estimate the association of metformin exposure (No DM\/No metformin; DM\/No metformin; DM\/Metformin) with event\u2010free (EFS), lymphoma\u2010specific (LSS) and overall (OS) survival. Compared to No DM\/No metformin DLBCL patients, there was no association of DM\/Metformin (<jats:italic>n<\/jats:italic>\u00a0=\u00a048; HR\u00a0=\u00a01\u00b705, 95% CI 0\u00b759\u20131\u00b789) or DM\/No metformin(<jats:italic>n<\/jats:italic>\u00a0=\u00a054; HR\u00a0=\u00a01\u00b741, 95% CI 0\u00b788\u20132\u00b726) with EFS; results were similar for LSS and OS. Compared to No DM\/No metformin FL patients, there was no association of DM\/Metformin (<jats:italic>n<\/jats:italic>\u00a0=\u00a037; HR\u00a0=\u00a01\u00b716, 95% CI 0\u00b771\u20131\u00b789) or DM\/No metformin (<jats:italic>n<\/jats:italic>\u00a0=\u00a019; HR\u00a0=\u00a01\u00b716, 95% CI 0\u00b766\u20132\u00b704) with EFS; results were similar for LSS. However, DM\/Metformin was associated with inferior OS (HR\u00a0=\u00a02\u00b717; 95% CI 1\u00b719\u20133\u00b795) compared to No DM\/No metformin. In conclusion, we found no evidence that metformin use was associated with improved outcomes in newly diagnosed DLBCL and FL.<\/jats:p>","DOI":"10.1111\/bjh.15997","type":"journal-article","created":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T14:02:27Z","timestamp":1559052147000},"page":"820-828","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Impact of metformin use on the outcomes of newly diagnosed diffuse large B\u2010cell lymphoma and follicular lymphoma"],"prefix":"10.1111","volume":"186","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1576-8341","authenticated-orcid":false,"given":"Yucai","family":"Wang","sequence":"first","affiliation":[{"name":"Division of Hematology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1867-0526","authenticated-orcid":false,"given":"Matthew J.","family":"Maurer","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa C.","family":"Larson","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristine","family":"Allmer","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew L.","family":"Feldman","sequence":"additional","affiliation":[{"name":"Division of Hematopathology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. Nora","family":"Bennani","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie A.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis F.","family":"Porrata","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Habermann","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Witzig","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M.","family":"Ansell","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L.","family":"Slager","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grzegorz S.","family":"Nowakowski","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7482-178X","authenticated-orcid":false,"given":"James R.","family":"Cerhan","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2016.1239822"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2012.075184"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24671"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyx119"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(14)00037-4"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4334-5"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2018.04.002"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx289"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-13-0424"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1314583"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-12-757740"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000011596"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2017.07.029"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(16)30040-0"},{"key":"e_1_2_8_16_1","article-title":"Metformin and colorectal cancer \u2013 a systematic review","author":"Kobiela J.","year":"2018","journal-title":"Experimental and Clinical Endocrinology & Diabetes"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2011.574752"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.73.2784"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01039"},{"key":"e_1_2_8_20_1","first-page":"1191","article-title":"Metformin use and its effect on gastric cancer in patients with type 2 diabetes: a systematic review of observational studies","volume":"15","author":"Li P.","year":"2018","journal-title":"Oncology Letters"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules190914304"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2018.05.023"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2016.11.011"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2018.03.002"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.151738"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2012.13"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.67.4044"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-17-0936"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-010-0707-5"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2018.07.006"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2014.04.007"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2010.226"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2017.57"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.307"},{"key":"e_1_2_8_35_1","first-page":"483","article-title":"Effects of metformin on survival outcomes of pancreatic cancer patients with diabetes: a meta\u2010analysis","volume":"8","author":"Xin W.","year":"2018","journal-title":"Molecular and Clinical Oncology"},{"key":"e_1_2_8_36_1","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1182\/blood-2018-99-112988","article-title":"A global, randomized, placebo\u2010controlled, phase 3 study of ibrutinib plus rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (RCHOP) in patients with previously untreated non\u2010germinal center B\u2010cell\u2010like (GCB) diffuse large B\u2010cell lymphoma (DLBCL)","volume":"132","author":"Younes A.","year":"2018","journal-title":"Blood"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.3892\/br.2015.417"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.15997","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.15997","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.15997","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T23:14:56Z","timestamp":1694301296000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.15997"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,28]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1111\/bjh.15997"],"URL":"https:\/\/doi.org\/10.1111\/bjh.15997","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,28]]},"assertion":[{"value":"2019-01-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}