{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:57:26Z","timestamp":1787237846863,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T00:00:00Z","timestamp":1560902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Vibration controlled transient elastography (VCTE) is validated for the evaluation of hepatic fibrosis in different liver diseases. Sickle cell liver disease (SCLD) results from a cumulative hepatic injury and its lifelong and progressive nature raises the need for a non\u2010invasive tool for fibrosis evaluation.<\/jats:p>\n                  <jats:p>\n                    Fifty patients, aged between 23 and 59\u00a0years with sickle cell disease and suspected SCLD underwent a VCTE followed by a liver biopsy. Biopsies were evaluated for various scores of liver disease that were then correlated to VCTE score. 90% of our patients had an Ishak Fibrosis (IF) score between 0\u20132 (Group A\u2010minimal to no fibrosis) and 10% of the patients had IF score between 3\u20136 (Group B\u2010advanced fibrosis). The median Transient Elastography (TE) for patients in Groups A\u00a0and B was 4\u00b78 kilopascals (kPa) and 17\u00b76\u00a0kPa, respectively. A positive correlation was shown between TE and IF score,\n                    <jats:italic>R<\/jats:italic>\n                    \u00a0=\u00a00\u00b70\u00b768 (\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    =\u00a0&lt;0\u00b70001); a positive\u00a0correlation was also shown with Histology Activity Index fibrosis score,\n                    <jats:italic>R<\/jats:italic>\n                    \u00a0=\u00a00\u00b764 (\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    =\u00a0&lt;0\u00b70001). This study emphasises the need for further studies of non\u2010invasive tools and their utility in liver fibrosis evaluation of patients with SCLD.\n                  <\/jats:p>","DOI":"10.1111\/bjh.16047","type":"journal-article","created":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T20:33:46Z","timestamp":1560976426000},"page":"117-123","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Vibration Controlled Transient Elastography (Fibroscan\u00ae) in sickle cell liver disease \u2010 could we strike while the liver is hard?"],"prefix":"10.1111","volume":"187","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6832-0903","authenticated-orcid":false,"given":"Gil","family":"Ben Yakov","sequence":"first","affiliation":[{"name":"Liver Diseases Branch NIDDK, NIH Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9352-625X","authenticated-orcid":false,"given":"Disha","family":"Sharma","sequence":"additional","affiliation":[{"name":"Liver Diseases Branch NIDDK, NIH Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hawwa","family":"Alao","sequence":"additional","affiliation":[{"name":"Liver Diseases Branch NIDDK, NIH Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pallavi","family":"Surana","sequence":"additional","affiliation":[{"name":"Liver Diseases Branch NIDDK, NIH Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9565-9868","authenticated-orcid":false,"given":"Devika","family":"Kapuria","sequence":"additional","affiliation":[{"name":"Liver Diseases Branch NIDDK, NIH Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ohad","family":"Etzion","sequence":"additional","affiliation":[{"name":"Liver Diseases Branch NIDDK, NIH Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3706-6615","authenticated-orcid":false,"given":"Matthew M.","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Molecular and Clinical Hematology Branch NHLBI, NIH Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Tisdale","sequence":"additional","affiliation":[{"name":"Molecular and Clinical Hematology Branch NHLBI, NIH Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney D.","family":"Fitzhugh","sequence":"additional","affiliation":[{"name":"Sickle Cell Branch NHLBI, NIH Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Kleiner","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology NCI, NIH Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliot B.","family":"Levy","sequence":"additional","affiliation":[{"name":"Interventional Radiology, Department of Diagnostic Radiology NIH Bethesda, MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Chang","sequence":"additional","affiliation":[{"name":"Interventional Radiology, Department of Diagnostic Radiology NIH Bethesda, MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elenita","family":"Rivera","sequence":"additional","affiliation":[{"name":"Liver Diseases Branch NIDDK, NIH Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Huang","sequence":"additional","affiliation":[{"name":"Liver Diseases Branch NIDDK, NIH Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Koh","sequence":"additional","affiliation":[{"name":"Liver Diseases Branch NIDDK, NIH Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theo","family":"Heller","sequence":"additional","affiliation":[{"name":"Liver Diseases Branch NIDDK, NIH Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-02-203323"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20317"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14277"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/15321819.2018.1495649"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.24114"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(55)90348-X"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2015.11.015"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23425"},{"key":"e_1_2_7_10_1","unstructured":"Centers for Disease Control and Prevention. (2019).Data & Statistics on Sickle Cell Disease | CDC. 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