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Peripheral blood or bone marrow mononuclear cells obtained at initial diagnosis from 194 patients with CLL were analysed to determine the ethnic difference in genetic abnormalities. Mutated <jats:italic>IGHV<\/jats:italic> was detected in 71\u00b72% of Taiwanese CLL and <jats:italic>IGHV3\u201023<\/jats:italic> was the most frequently used gene. Stereotyped BCR was present in 18\u00b73% with subset 8 being the most frequent. All cases with subset 8 belonged to <jats:italic>IGHV 4\u201039<\/jats:italic> and were exclusively associated with un\u2010mutated <jats:italic>IGHV<\/jats:italic> and poor outcome. Mutation frequencies of <jats:italic>SF3B1<\/jats:italic> (9\u00b77%), <jats:italic>NOTCH1<\/jats:italic> (8\u00b76%), <jats:italic>BIRC3<\/jats:italic> (1\u00b71%), <jats:italic>ATM<\/jats:italic> (16\u00b79%) or <jats:italic>TP53<\/jats:italic> (8\u00b71%), and frequencies of cytogenetic abnormalities including trisomy 12 (18\u00b76%), del(17p) (10\u00b74%), del(13q) (43\u00b77%) and <jats:italic>IGH<\/jats:italic> translocation (10\u00b71%) were comparable to those reported from Western countries, except del(11q) (6\u00b79%) which was lower in our patients. Patients with un\u2010mutated <jats:italic>IGHV<\/jats:italic>, subset 8, disrupted <jats:italic>TP53<\/jats:italic>, trisomy 12, and <jats:italic>SF3B1<\/jats:italic> mutations had a worse outcome compared to patients without these mutations. In conclusion, <jats:italic>IGHV3\u201023<\/jats:italic> usage, stereotyped subset 8 and lower frequency of del(11q) show an ethnicity\u2010dependent association in Taiwanese CLL patients.<\/jats:p>","DOI":"10.1111\/bjh.16051","type":"journal-article","created":{"date-parts":[[2019,6,23]],"date-time":"2019-06-23T22:44:26Z","timestamp":1561329866000},"page":"82-92","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Distinct immunoglobulin heavy chain variable region gene repertoire and lower frequency of del(11q) in Taiwanese patients with chronic lymphocytic leukaemia"],"prefix":"10.1111","volume":"187","author":[{"given":"Ying\u2010Jung","family":"Huang","sequence":"first","affiliation":[{"name":"Division of Haematology\u2010Oncology Chang Gung Memorial Hospital at Linkou Taoyuan 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