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The majority of patients were diagnosed via random skin biopsy (29\/42, 69\u00b70%) followed by bone marrow biopsy alone (8\/42, 19\u00b70%). Characteristic features included persistent fever (41\/42, 97\u00b76%), decreased performance status (\u22652) (100%), hypoxaemia (32\/40, 80\u00b70%), impaired consciousness (19\/42, 45\u00b72%), hypoalbuminemia (42\/42, 100%) and extreme elevation of lactate dehydrogenase and soluble interleukin 2 receptor levels. Brain magnetic resonance imaging showed abnormal findings in 32\/37 patients (86\u00b74%). Hyperintense lesion in the pons was a peculiar finding that was unrelated to the neurological deficits. Positron emission tomography\u2010computed tomography revealed a high incidence of bone marrow (26\/34, 76\u00b75%), spleen (19\/34, 55\u00b79%) and adrenal gland (9\/34, 26\u00b75%) involvement. Neurolymphomatosis was noted in 6 patients during the course of the disease. About 60% of IVLBCL patients in whom <jats:italic>in vivo<\/jats:italic> diagnosis was possible survived more than 5\u00a0years with combination chemotherapy. Our observations provide additional insight into the diagnosis of IVLBCL and indicate that early disease recognition via random skin biopsy combined with imaging, enables <jats:italic>in vivo<\/jats:italic> diagnosis of the disease and improved survival for many patients.<\/jats:p>","DOI":"10.1111\/bjh.16081","type":"journal-article","created":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T07:56:15Z","timestamp":1562140575000},"page":"328-336","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":84,"title":["Diagnosis of intravascular large B cell lymphoma: novel insights into clinicopathological features from 42 patients at a single institution over 20\u00a0years"],"prefix":"10.1111","volume":"187","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8669-9865","authenticated-orcid":false,"given":"Kosei","family":"Matsue","sequence":"first","affiliation":[{"name":"Division of Haematology\/Oncology, Department of Internal 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