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UCBT affords a lower incidence of graft\u2010\n                    <jats:italic>versus<\/jats:italic>\n                    \u2010host disease compared to alternative stem cell sources, but also presents a slower immune recovery and a high risk of infections if serotherapy is not omitted or targeted within the conditioning regimen. The selection of UCB units with high cell content and good human leucocyte antigen match is essential to improve the outcome. Techniques, such as double UCBT,\n                    <jats:italic>ex vivo<\/jats:italic>\n                    stem cell expansion and intra\u2010bone injection of UCB, have improved cord blood engraftment, but clinical benefit remains to be demonstrated. Cell therapies derived from UCB are under evaluation as potential novel strategies to reduce relapse and viral infections following transplantation. In recent years, improvements within haploidentical transplantation have reduced the overall use of UCBT as an alternative stem cell source; however, each may have its relative merits and disadvantages and tailored use of these alternative stem cell sources may be the optimal approach.\n                  <\/jats:p>","DOI":"10.1111\/bjh.16107","type":"journal-article","created":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T21:29:15Z","timestamp":1565731755000},"page":"650-683","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Current status of umbilical cord blood transplantation in children"],"prefix":"10.1111","volume":"190","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6226-9895","authenticated-orcid":false,"given":"Maria","family":"Gabelli","sequence":"first","affiliation":[{"name":"Bone Marrow Transplantation Great Ormond Street Hospital London 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