{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T22:49:50Z","timestamp":1788648590330,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T00:00:00Z","timestamp":1564704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670118"],"award-info":[{"award-number":["81670118"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Acquired haemophilia A (AHA) is a rare haemorrhagic disorder caused by autoantibodies directed against the functional epitopes of coagulation factor VIII (FVIII). Its management relies on prompt diagnosis, control of bleeding and eradication of the inhibitor by immunosuppression. China Acquired Hemophilia Registry (CARE), a nationwide multicentre registry, was intended to survey the status of AHA and standardize its diagnosis and therapy in China. One hundred and eighty\u2010seven registered patients had an average age of 52\u00a0years. Diagnosis was delayed in 46\u00b75% patients. There was a significant delay from diagnosis to immunosuppressive therapy in 68\u00b73% patients. Bleeding control was significantly higher in patients treated with prothrombin complex concentrate (PCC)\n                    <jats:italic>versus<\/jats:italic>\n                    FVIII replacement therapy (84\u00b76% vs. 34\u00b74%;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00\u00b7001). Inhibitor eradication with a combination of steroids and cyclophosphamide showed a higher partial remission (PR) rate (92\u00b72% vs. 70\u00b73%) and stable complete remission (CR) rate (82\u00b78% vs. 48\u00b76%) than with steroids alone. Logistic regression model showed age and malignancy were significantly related to survival at final follow\u2010up. The mean age for the survivors [51\u00a0years (IQR, 35\u201365\u00a0years)] was significantly lower than that of the non\u2010survivors [79\u00a0years (IQR, 67\u201386\u00a0years)] (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00\u00b7001). Overall survival was higher in non\u2010malignancy group than malignancy group (94\u00b79% vs. 70%) (OR\u00a0=\u00a01\u00b7313; 95% CI, 0\u00b7913\u20131\u00b7889,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00\u00b7015).\n                  <\/jats:p>","DOI":"10.1111\/bjh.16128","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T08:11:59Z","timestamp":1564733519000},"page":"653-665","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Outcome of CARE: a 6\u2010year national registry of acquired haemophilia A in China"],"prefix":"10.1111","volume":"187","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6334-5258","authenticated-orcid":false,"given":"Boyang","family":"Sun","sequence":"first","affiliation":[{"name":"State Key Laboratory of Experimental Haematology, National Clinical Research Centre for Haematological Disorders Institute of Haematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin Laboratory of Blood Disease Gene Therapy, CAMS Key Laboratory of Gene Therapy for Blood Diseases Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Xue","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Haematology, National Clinical Research Centre for Haematological Disorders Institute of Haematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin Laboratory of Blood Disease Gene Therapy, CAMS Key Laboratory of Gene Therapy for Blood Diseases Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Haematology Second Affiliated Hospital of Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Sun","sequence":"additional","affiliation":[{"name":"Nanfang Hospital Nanfang Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqiang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Haematology The First Affiliated Hospital of Soochow University Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Haematology Qilu Hospital, Shandong University Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4476-4304","authenticated-orcid":false,"given":"Jingyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Haematology, Key Laboratory of Haematology of Hebei Province The Second Hospital of Hebei Medical University Shijiazhuang Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion The Affiliated Hospital of Guizhou University Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqiang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Haematology Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimei","family":"Lian","sequence":"additional","affiliation":[{"name":"Department of Haematology Dalian Municipal Central Hospital, Affiliated Hospital of Dalian Medical University Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meijuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Fujian Institute of Haematology Fujian Medical University Union 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