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Phenotypic patterns were determined by immunohistochemistry (IHC) of pathological samples from patients with HIV\u2010associated DLBCL prospectively enrolled in the French AIDS and Viral Hepatitis CO16 Lymphovir cohort between 2008 and 2015. Molecular subgroup classification into germinal centre B\u2010cell (GCB) and non\u2010GCB subtypes was determined using the Hans algorithm. Among 52 samples of systemic DLBCL subjected to centralized pathological analysis, 25 of the 42 tested for BCL2 expression were positive. Samples were further classified into GCB (<jats:italic>n<\/jats:italic>\u00a0=\u00a019) and non\u2010GCB (<jats:italic>n<\/jats:italic>\u00a0=\u00a016) subtypes and 17 remained unclassified. In multivariable analysis, BCL2 expression was an independent pejorative prognostic biomarker [4\u2010year progression\u2010free survival (PFS): 52% for BCL2<jats:sup>+<\/jats:sup> vs. 88% for BCL2<jats:sup>\u2212<\/jats:sup>, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b702] and tended to reduce 4\u2010year overall survival (OS) (63% for BCL2<jats:sup>+<\/jats:sup> vs. 88% for BCL2<jats:sup>\u2212<\/jats:sup>, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b706). The difference between CGB and non\u2010GCB subtypes on PFS and OS did not reach significance (4\u2010year PFS: 79% for GCB vs. 53% for non\u2010GCB, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b724 and 4\u2010year OS: 78% for GCB vs. 69% for non\u2010GCB, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b734). BCL2 expression determined by IHC is an independent pejorative prognostic biomarker in HIV\u2010associated DLBCL in the recent era. This supports the investigation of new therapeutic strategies in patients with BCL2 expression.<\/jats:p>","DOI":"10.1111\/bjh.16176","type":"journal-article","created":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T02:41:13Z","timestamp":1567132873000},"page":"413-423","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["<i>In situ<\/i> BCL2 expression is an independent prognostic factor in HIV\u2010associated DLBCL, a LYMPHOVIR cohort study"],"prefix":"10.1111","volume":"188","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1121-2610","authenticated-orcid":false,"given":"Laure","family":"Philippe","sequence":"first","affiliation":[{"name":"Unit of Haematology-Oncology Centre Hospitalier Versailles Le Chesnay France"},{"name":"Universit\u00e9 Versailles Saint Quentin en Yvelines, Paris\u2010Saclay University, Communaut\u00e9 Paris\u2010Saclay Saint-Quentin en Yvelines 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